2016 American Transplant Congress
The Largest Single Center Experience with Total Artificial Heart Implantation: Characterization of Outcome.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Patients with severe irreversible biventricular heart failure may require support with the total artificial heart (TAH). These patients are usually Intermacs level 1 or…2016 American Transplant Congress
Pregnancy Outcomes in 17 Female Heart Transplant Recipients with the Initial Diagnosis of Congenital Heart Defect.
The purpose of this study was to describe pregnancy in female heart recipients whose indication for transplantation was due to congenital heart defect. Data were…2016 American Transplant Congress
miR-21 in Chronic Allograft Vasculopathy.
Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…2016 American Transplant Congress
Ameliorating Progression of Allograft Vasculopathy by Targeting the T Follicular Helper Cell Subset.
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
BACKGROUNDDevelopment of long-lived alloantibody is closely linked with chronic rejection and graft failure. We examined in a murine model of antibody-mediated rejection (AMR) if targeting…2016 American Transplant Congress
Conditional Deletion of mTOR in Myeloid Cells Inhibits Chronic Allograft Rejection – A Novel Role for Macrophages in Transplant Vasculopathy.
Most transplants eventually lost to chronic rejection under potent immunosuppression therapies where activation of innate immunity is suspected to play a major role in graft…2016 American Transplant Congress
BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.
Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…2016 American Transplant Congress
Obliterative Bronchiolitis Following Lung Transplantation Is Preceded by Depletion of Airway Submucosal Glands and Basal Stem Cells.
University of Iowa, Iowa City, IA.
Background: Obliterative bronchiolitis (OB), a major cause of morbidity and mortality following lung transplantation, is characterized by progressive fibrosis of distal airways. We hypothesized that…2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…2016 American Transplant Congress
Hif-1α Stabilization in the Recipient Accelerates Cardiac Allograft Rejection.
Northwestern University, Chicago.
Introduction: Increased Hif-1α mRNA expression in deceased-donor organ transplant tissue prior to or soon after transplantation significantly correlated with primary graft dysfunction. HIF-1α is positioned…2016 American Transplant Congress
Foxp3 Controls Oxidative Phosphorylation in Regulatory T Cells.
Current immunosuppressive therapies are limited by non-specificity and toxicities, and new pharmacologic approaches to immunosuppressive therapies are needed. Many T cell subsets have distinct metabolic…
American Transplant Congress abstracts