2016 American Transplant Congress
An Interventional Study Evaluating Cell Mediated Immunity to Guide Therapy for CMV Viremia.
Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.
BackgroundPatients treated for CMV viremia commonly relapse after discontinuation of therapy. CMV-specific CD8+ T-cell mediated immunity (CMI) is useful to predict the risk of CMV…2016 American Transplant Congress
Cytometric Deep Profiling of the CD8+ T-Cell Compartment in Transplant Patients with CMV Viremia.
Background: Cytomegalovirus (CMV) infection is a common opportunistic viral infection in transplant patients. Patterns of viremia and relapse are influenced by the host immune response,…2016 American Transplant Congress
Assessing Return of CMV Specific Cellular Immunity Using the T-SPOT.CMV Soon After Kidney Transplant with Thymoglobulin.
Infectious Disease, Massachusetts General Hospital, Boston, MA.
Background: We do not currently have sufficient predictive tools to determine risk of CMV infection after organ transplantation. Recent data suggest that assays of the…2016 American Transplant Congress
Association of Cytomegalovirus-Specific T Cell-Mediated Immunity with the Risk of CMV Infection Occurrence in Kidney Transplant Recipients.
Introduction CMV remains the significant cause of morbidity in transplant recipients. Despite universal prophylaxis, late CMV infection occurs in high proportion of kidney transplant recipients.…2016 American Transplant Congress
Human MicroRNA Responses Are Predictive of CMV Reactivation Following Solid Organ Transplant.
Background: Human microRNA (miRNA) can suppress gene expression through binding to the 3' untranslated region (UTR) of the target mRNA. In silico analysis shows that,…2016 American Transplant Congress
The Quilty Effect in Pediatric Heart Transplant Recipients.
Purpose: The Quilty effect is defined as the presence of a nodular endocardial infiltrate of lymphocytes in an endomyocardial biopsy (EMB), and has been described…2016 American Transplant Congress
Solid Phase Assay Demonstrates High Rates of Allosensitization in Pediatric Heart Recipients.
Allosensitization is a risk factor for rejection, vasculopathy and graft loss. CTOTC-04 is a prospective study assessing the impact of sensitization on a composite of…2016 American Transplant Congress
A Risk Quantification Score for Heart Transplants: A Heart Donor Risk Index.
Background: To better risk stratify heart transplants, we developed a continuous heart donor risk index (HDRI) based on heart donors to quantify heart allograft failure.Methods:…2016 American Transplant Congress
The Impact of Complement Binding Donor Specific Antibodies in the First Year After Heart Transplantation.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: The development of donor specific antibodies (DSA) after heart transplant has been associated with poor outcome. We now have the ability to assess the…2016 American Transplant Congress
Dilution of Patient Sera Improves MFI Correlation with Complement Fixation in Solid Phase Assay Assessment.
Background: Median Fluorescent Intensity (MFI) by solid phase assays (SPA) has been used to determine risk of donor-recipient reaction prior to transplant. Inconsistency of this…
American Transplant Congress abstracts