2016 American Transplant Congress
Visceral Adiposity Is Associated with Increased Recurrence of Hepatocellular Carcinoma Following Liver Transplantation.
Abdominal Transplant, Columbia University, Ny, NY.
IntroductionObesity has become a worldwide epidemic. The number of patients with HCC undergoing Orthotopic liver transplant (OLT) is rising. Epidemiologic evidence suggests a link between…2016 American Transplant Congress
Early Post-Transplant Immunosuppression (IS) Withdrawal – Final Outcomes of the ITN030ST AWISH Study.
ITN030ST is a prospective randomized trial designed to determine the clinical benefit of early IS withdrawal in adult liver transplant (LT) recipients. Recipients did not…2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…2016 American Transplant Congress
Seven Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
1Northwestern University, Chicago; 2University of Louisville, Louisville.
36 subjects have been enrolled and 31 transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts…2016 American Transplant Congress
HLA Identical or Haploidentical Combined Kidney and Bone Marrow Transplantation for Multiple Myeloma with End-Stage Renal Failure.
1Massachusetts General Hospital, Boston; 2Columbia University, New York.
Patients with multiple myeloma (MM) who developed end-stage renal disease (ESRD) are generally not eligible for either kidney transplantation or allogeneic stem-cell transplant. We performed…2016 American Transplant Congress
Tolerance Induction with Donor Bone Marrow Transplantation in Kidney Transplantation.
Tolerance induction is considered to be a final goal in the field of organ transplantation. We have performed simultaneous bone marrow and kidney transplantation in…2016 American Transplant Congress
Clonal Expansion of Donor-Specific Tregs Following Combined Kidney and Bone Marrow Transplantation.
HLA-mismatched allograft tolerance was intentionally induced via combined kidney and bone marrow transplant (CKBMT) in two ITN protocols (NKDO3 and ITN036ST), but the mechanisms of…2016 American Transplant Congress
Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in De Novo Living Donor Kidney Transplant Recipients.
1Northwestern University, Chicago; 2NMH, Chicago; 3TRACT Therapeutics, Chicago.
Therapeutic cell transfer using regulatory T cells (Tregs) holds the promise of reducing the need for drug based immunosuppression (IS) and improving long term graft…2016 American Transplant Congress
Initial Experience with Donor Specific Tregs in Kidney Transplantation.
Systematic multicenter clinical evaluation of regulatory cells is being conducted by the EU supported ONE Study trial in which each site is administering a different…2016 American Transplant Congress
A Prospective Carfilzomib-Based Desensitization Trial: Phase 1 Results.
1U Of Cincinnati, Cincinnati; 2Mayo Clinic, Phoenix.
Carfilzomib (CFZ) is mechanistically distinct from bortezomib as it is an irreversible PI. Results from phase 1 of a CFZ desensitization (DS) trial are presentedMethods:…
American Transplant Congress abstracts