ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Early Proteomic Predictors of Late Chronic Kidney Disease in Liver Transplant Recipients.

    J. Levitsky,1 S. Asrani,2 L. Zhao,1 M. Abecassis,1 L. Jennings,2 G. Klintmalm.2

    1Northwestern, Chicago; 2Baylor, Dallas.

    Background: A high proportion of patients develop chronic kidney disease (CKD) after liver transplantation (LT). However, the ability to better select patients for nephroprotective interventions…
  • 2016 American Transplant Congress

    25-Hydroxyvitamin D Insufficiency Is Associated with Higher Risk of BK Virus Re-Activation After Kidney Transplantation.

    N. Elfadawy,1 S. Flechner,2 E. Poggio,2 B. Stephany,2 R. Fatica,2 J. Schold,2 S. Mossad.2

    1Internal Medicine, Case Western Reserve University, Cleveland, OH; 2Cleveland Clinic, Cleveland, OH.

    BACKGROUND: The past decade has seen increased interest in vitamin D, as new data suggest that it plays a role in the immune system. The…
  • 2016 American Transplant Congress

    BK Polyomavirus Seroreactivity of Kidney Donors Predicts Viremia and Nephropathy in Recipients.

    H. Wunderink,1 E. van der Meijden,1 C. van der Blij-de Brouwer,1 M. Mallat,2 G. Haasnoot,3 E. van Zwet,4 E. Claas,1 J. de Fijter,3 A. Kroes,1 F. Arnold,5 A. Touzé,5 F. Claas,3 J. Rotmans,3 M. Feltkamp.1

    1Medical Microbiology, LUMC, Leiden, Netherlands; 2Nephrology, LUMC, Leiden, Netherlands; 3Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands; 4Medical Statistics and Bioinformatics, LUMC, Leiden, Netherlands; 5UMR INRA 1282 ISP, Université François Rabelais, Tours, France.

    Background Kidney transplant (KTx) donors are not implicated in predicting BK polyomavirus (BKV) infection in the recipient. For BKV-associated nephropathy (BKVAN) however, donor origin of…
  • 2016 American Transplant Congress

    Immune Response to BK Virus in Renal Transplant Recipients.

    D. DeWolfe,1 J. Gandhi,1 M. Mackenzie,1 T. Broge,1 E. Bord,1 D. Mandelbrot,1 R. Viscidi,2 F. Cardarelli,1 M. Pavlakis,1 C. Tan.1

    1Medicine, Beth Israel Deaconess Medical Center, Boston, MA; 2Pediatrics, Johns Hopkins Medical Center, Baltimore, MD.

    Background: The adaptive immune characteristics associated with BK Virus (BKV) infection and control remain incompletely described. In this study we further elucidate the immune response…
  • 2016 American Transplant Congress

    Influence of the Tacrolimus Metabolism Rate on BKV Infection After Kidney Transplantation.

    G. Thölking,1 C. Schmidt,1 K. Schuette-Nuetgen,1 D. Pabst,1 R. Koch,2 H. Wolters,3 S. Reuter,1 B. Suwelack.1

    1Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany; 2Institute of Biometrics and Clinical Research, University of Münster, Münster, Germany; 3Department of General Surgery, University Hospital of Münster, Münster, Germany.

    Introduction: BK virus (BKV) infection is a serious complication following renal transplantation (RTx). The minimization of risk factors that predict BKV infection might help to…
  • 2016 American Transplant Congress

    BK Nephropathy, but Not Isolated BK Viremia Associated with De Novo DSA Despite Similar Immunosuppression Reduction.

    W. Cheungpasitporn,1 D. Mitema,1 H. Amer,1 F. Cosio,1 M. Stegall,2 C. Schinstock.1

    1Nephrology and Hypertension, Mayo Clinic, Rochester, MN; 2Transplantation Surgery, Mayo Clinic, Rochester, MN.

    Introduction: Reduced immunosuppression is associated with de novo DSA (dn DSA). Although immunosuppression is often reduced in patients with polyomavirus (BK), the incidence of dn…
  • 2016 American Transplant Congress

    Potential Applications of Viral miRNA Assays in the Management of Transplant Patients with Polyomavirus BK Infection.

    P. Randhawa, G. Zeng, Y. Huang.

    Department of Pathology, The Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA.

    Background: BKV encodes two miRNAs from a single precursor: BKV-miR-B1-5p & BKV-JCV-miR-BJ1-3p. These viral miRNAs direct cleavage of large T antigen mRNAs, downregulate viral T…
  • 2016 American Transplant Congress

    HLA Class II and BK Virus Reactivation in Renal Transplant Recipients.

    P. Shah,1 K. Anderson,2 M. Aubrey,2 C. Roark,2 B. Freed,2 A. Wiseman.1

    1Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO; 2Division of Immunology, University of Colorado School of Medicine, Aurora, CO.

    BK Viremia (BKV) and subsequent BK nephropathy are associated with renal graft loss. The Human Leukocyte Antigen (HLA) region has been implicated in susceptibility to…
  • 2016 American Transplant Congress

    Potent Induction Therapy Improves Graft Outcome in Younger Pancreas Transplant Recipients (<30 Years of Age).

    A. Gruessner, V. Whittaker, S. Narsipur, V. Aggarwal, C. Hubbel, R. Gruessner.

    SUNY Upstate Medical University, Syracuse, NY.

    Purpose: Pancreas transplants (tx) are increasingly performed in older patients with type 1 diabetes mellitus. This trend may be explained by the significantly higher immunologic…
  • 2016 American Transplant Congress

    The Impact of One Year Individual or Dual Organ Rejection in Simultaneous Pancreas-Kidney Transplant on Kidney Graft Survival – A UNOS Registry Analysis 2000-2013.

    I. Moinuddin,1 T. Taber,1 M. Yaqub,1 O. Adebiyi,1 M. Mujtaba,1 J. Chen,2 M. Goble,2 D. Mishler,1 J. Fridell,2 A. Sharfuddin.1

    1Medicine/Nephrology, Indiana University, Indianapolis; 2Surgery/Transplant, Indiana University, Indianapolis.

    Background: Early Rejection of either organ in Simultaneous Pancreas-Kidney transplants (SPK) is common within the first 1 year. We studied the impact of within 1…
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