2016 American Transplant Congress
Pulse Wave Velocity Amongst African-American Kidney Transplant Recipients Randomized to Once-Daily MeltDose Tacrolimus Tablets (Envarsus XR) vs. Traditional Twice-Daily Tacrolimus Capsules: Exploratory Results from a Phase III Trial.
Cardiovascular (CV) death is a leading cause of death in kidney transplant recipients (KTR). Increased aortic arterial stiffness is strongly associated with the development of…2016 American Transplant Congress
Therapeutically Equivalent Results to Caucasians in Black Kidney Transplant Recipients Using ASTAGRAF XL® Despite a Higher Degree of HLA Mismatch : A Post-Hoc Analysis of Phase III Data from Over 2000 Patients.
Astelleas Pharma Global Develepment, Northbrook, IL.
INTRO: When contemplating the use of a new immunosuppressant agent in kidney transplantation, measuring outcomes in potentially vulnerable populations is of paramount concern. As such,…2016 American Transplant Congress
Determinants of 1 Year Graft Loss After Pre Kidney Transplant Bariatric Surgery.
Medical Unversity of South Carolina, Charleston, SC.
Background: Bariatric surgery (BS) is increasingly used to manage weight pre-transplantation (Pre-Tx). However, grafts may be compromised by variable drug absorption, rejection and oxalate nephropathy.…2016 American Transplant Congress
The UK ONE Study: Safety and Feasibility of Regulatory T Cell Therapy in Renal Transplantation.
Introduction: The UK ONE Study trial investigates the safety and feasibility of regulatory T (Treg) cell therapy in renal transplantation.Materials and Methods: Eleven (9m;2f) living…2016 American Transplant Congress
Serial Peripheral Blood Mononuclear Cell Expression Profiling Reveals Inflammatory Genomic Storm Following Mechanical Circulatory Support Surgery.
Introduction: The main cause of death in patients with Advanced Heart Failure (AdHF) is the Multi-Organ Dysfunction (MOD) Syndrome. Immune system aberrancy after Mechanical Circulatory…2016 American Transplant Congress
A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.
Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…2016 American Transplant Congress
Primary Graft Failure following Cardiac Transplantation Is Associated with Elevated Pre-Transplant Levels of Pro-Inflammatory Factors.
Primary graft failure (PGF) is defined as severe ventricular dysfunction immediately following heart transplantation (HTx) requiring temporary mechanical circulatory support (MCS) such as VA ECMO…2016 American Transplant Congress
A New Diagnostic Score for Microvascular Inflammation in Antibody-Mediated Rejection in Heart Transplantation.
BackgroundThe ISHLT working formulation defines Intravascular Activated Mononuclear Cells (IAMC) as one of the histopathologic features of antibody-mediated rejection (ABMR) in heart transplantation. However, no…2016 American Transplant Congress
Donor-Specific Antibody Is a Major Independent Predictor of Accelerated Heart Allograft Vasculopathy (CAV).
Introduction The role of circulating DSA in addition to traditional cardiovascular risk factors, in the development of accelerated CAV have not been demonstrated. We investigated…
American Transplant Congress abstracts