2016 American Transplant Congress
An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.
Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…2016 American Transplant Congress
Liver Transplantation (LT) Using Liver Allografts from Deceased After Cardiac Death (DCD) Donors: Opinions, Practices and Reality.
Background: Scientific Studies Committee of ASTS conducted study to identify barriers to use of DCD liver grafts.Objectives: Identify barriers to use of DCD liver allografts;…2016 American Transplant Congress
Potential Biomarkers and Treatment for BK Virus Associated Nephropathy.
Background: BK polyomavirus assoiciated nephropathy (BKVAN) is one of the major complications in renal transplants, and is associated with significant fibrosis It is important to…2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…2016 American Transplant Congress
Accepted Mouse Kidney Allografts Are Characterized by Widespread Nitrosylation.
Leukocytes can modulate the immune response through manipulation of amino acid metabolism. Research indicates that depletion of L-arginine and generation of nitric oxide (NO) suppresses…2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…2016 American Transplant Congress
Real Time Assessment of Kidney Transplant Indication Biopsies by Microarrays: First Results of the INTERCOMEX Study.
1University of Alberta, Edmonton, Canada; 2ATAGC, Edmonton, Canada.
Oncology uses central molecular tissue assessment (MTA) to guide management but the potential of this approach in transplantation is not known. We undertook a prospective…2016 American Transplant Congress
Kidney Transplant Recipient Adherence Measured by Proportion of Days Covered Is Associated with Late Biopsy Proven Acute Rejection.
While medication non-adherence is a known risk factor for late “biopsy proven acute rejection (BPAR),” the Pharmacy Quality Alliance definition of “proportion of days covered…2016 American Transplant Congress
Initial Experience with the Bacterial Enzyme IdeS® (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Patients.
Introduction: The IgG degrading enzyme derived from Streptococcus pyogenes (IdeS®) is a 35k-Da cysteine protease that cleaves human IgG molecules at the lower hinge region…
American Transplant Congress abstracts