ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Donor-Derived Toxoplasmosis in Solid Organ Transplant 2008 – 2015: Opportunities for Improvement.

    C. Wolfe,1 A. Wilk,2 S. Tlusty,2 C. Sifri,1 M. Morris,1 A. Mehta,1 D. Kaul.1

    1DTAC, Richmond, VA; 2United Network for Organ Sharing, Richmond, VA.

    Background: Donor-derived Toxoplasmosis (DDT) is uncommon, but outcomes may be poor. Donor risk factors are difficult to recognize, and donor screening is not currently universally…
  • 2016 American Transplant Congress

    Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.

    R. Sosa,1 A. Zarrinpar,2 C. Lassman,1 R. Busuttil,2 D. Gjertson,1 J. Kupiec-Weglinski,1 E. Reed.1

    1Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; 2Surgery, University of California-Los Angeles, Los Angeles, CA.

    Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
  • 2016 American Transplant Congress

    Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.

    B. Bruinsma,1 J. Avruch,2 G. Sridharan,1 P. Weeder,1 N. Karimian,1 J. Markmann,2 K. Uygun,1 H. Yeh.2

    1Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; 2Transplant Center, Massachusetts General Hospital, Boston, MA.

    Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…
  • 2016 American Transplant Congress

    Outcomes of Liver Grafts from Donors with Very High Transaminases.

    P. Martins, A. Rawson, P. Mahboub, B. Movahedi, N. Dolgin, I. Bruggenwirth, A. Bozorgzadeh.

    Department of Surgery, Transplant Division, University of Massachusetts, Worcester, MA.

    Introduction: Traditionally, elevation of transaminases has been broadly used as markers of hepatic ischemic injury and crucial parameters for liver graft assessment. We wanted to…
  • 2016 American Transplant Congress

    In Situ Aortic Flush with Lactated Ringer's (LR) Solution During Donation After Brain Death (DBD) Organ Procurement Provides Similar Outcomes and Significantly Decreases Costs in Kidney and Liver Transplantation Compared to Standard Preservation Solutions.

    S. Rudich, P. Lange.

    Medical Division, Gift of Life Michigan, Ann Arbor, MI.

    PURPOSE: To determine if LR, when used as the initial in situ aortic flush during DBD renal and hepatic procurement, was safe, effective, and non-inferior…
  • 2016 American Transplant Congress

    Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.

    Q. Liu, A. Nassar, G. Iuppa, B. Soliman, L. Buccini, M. Blum, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland, OH.

    One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…
  • 2016 American Transplant Congress

    The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.

    P. Diuwe,1 P. Domagala,1 R. Kieszek,1 M. Wszola,1 M. Serwanska-Swietek,1 L. Paczek,2 M. Durlik,3 A. Chmura,1 A. Kwiatkowski.1

    1Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; 2Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; 3Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.

    Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…
  • 2016 American Transplant Congress

    Differential Effect of Delayed Graft Function (DGF) on Kidney Transplant Outcomes: When Does DGF Not Make a Difference?

    M. Khan,1 H. El-Hennawy,1 A. Farney,1 J. Rogers,1 G. Orlando,1 A. Reeves-Daniel,2 A. Palanisamy,2 M. Gautreaux,3 S. Iskandar,3 W. Doares,4 S. Kaczmorski,4 R. Stratta.1

    1Surgery, Wake Forest, Winston-Salem, NC; 2Internal Medicine, Wake Forest, Winston-Salem, NC; 3Pathology, Wake Forest, Winston-Salem, NC; 4Pharmacy, Wake Forest, Winston-Salem, NC.

    Delayed graft function (DGF), defined as need for dialysis in 1st week following kidney transplant (KT), is an early surrogate marker of organ quality and…
  • 2016 American Transplant Congress

    Kidney Transplants from Anuric Deceased Donors on Renal Replacement Therapy.

    W. Bry, J. Bellingham, S. Katznelson, P. Patel, K. Ueda, H. Mahanty, N. Neidlinger, A. Hassoun, V. Peddi.

    Transplantation, California Pacific Medical Center, San Francisco, CA.

    Transplantation of deceased donor kidneys with Acute Kidney Injury (AKI) has become a generally well accepted practice with excellent results documented in the literature. The…
  • 2016 American Transplant Congress

    Significance of Preservation Fluid Cultures in Solid Organ Transplantation.

    H. Nam, N. Perni, K. Galen, M. Campara, R. Roca-Garcia, V. Yeldandi.

    University of Illinois at Chicago, Chicago.

    Introduction. The study aim was to determine microbiological characteristics of preservation fluid (PF) cultures in solid organ transplant (SOT) patients and to evaluate their impact…
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