Abstracts Archive - Page 1265 of 1683 - ATC Abstracts

2016 American Transplant Congress
Kidney Transplant with Low Level DSA and Low Positive B-Flow Crossmatch: An Underappreciated Option for Highly Sensitized Transplant Candidates.
C. Schinstock, W. Cheungpasitporn, F. Cosio, D. Mitema, M. Gandhi, M. Prieto, P. Dean, M. Stegall.
Transplant Center, Mayo Clinic, Rochester, MN.
Introduction: Avoiding DSA is difficult in sensitized patients. A kidney transplant (KTx) with low level DSA with or without a low level B flow cytometric…
2016 American Transplant Congress
Posttransplant AT1Rabs Precede De Novo HLA-DSA Development.
J. Arreola-Guerra,³ E. Cuevas,¹ E. Hernandez-Mendez,¹ M. Vilatoba,¹ A. Contreras,¹ J. Ramirez,¹ D. de Rongs,¹ J. Granados,¹ L. Morales-Buenrostro,² J. Alberu.¹
¹Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; ²Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; ³Tranplantation, Instituto de Servicios de Salud del Estado de Aguascalientes, Aguascalientes, Mexico.
Angiotensin II type 1 receptor antibodies (AT1Rabs) have been associated with acute allograft rejection and graft loss. The possible implication of the generation of de…
2016 American Transplant Congress
Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.
J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.
Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
2016 American Transplant Congress
C1q Donor Specific Antibody Associates with Post Transplant Biopsy Findings in Highly Sensitized Kidney Transplant Recipients.
S. Kuppachi,¹ D. Holanda,² S. Gallegos,³ E. Field.^3,4
¹Nephrology, University of Iowa Hospitals and Clinics, Iowa City, IA; ²Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA; ³Iowa Regional Histocompatibility and Immunogenetics Laboratory, Veteran Affairs Medical Center, Iowa City, IA; ⁴Immunology, University of Iowa Hospitals and Clinics, Iowa City, IA.
We performed monitoring of conventional donor specific antibodies (DSA) and C1q binding DSA (C1q DSA) to correlate levels with pathology findings in protocol kidney biopsies…
2016 American Transplant Congress
Focal C4d Staining in Biopsies of Kidney Transplant Recipients Is Not Associated with Antibody Mediated Rejection and Does Not Correlate with Graft Survival.
R. Prashar, M. Goggins, L. Yessayan, A. Patel, M. Goggins.
Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While diffuse C4d positivity in kidney transplant peritubular capillaries(PTC) strongly co-relates with the presence of antibody mediated rejection(AMR),data on the significance of focal C4d…
2016 American Transplant Congress
Donor Specif Antibody (DSA) Kinetics in Patients with Antibody Mediated Rejection (AMR) Treated with Plasmapheresis and Bortezomib.
L. Requião-Moura,¹ M. Afonso,² A. Sakashita,³ M. Silva,¹ A. Matos,¹ A. Pacheco-Silva.¹
¹Kidney Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; ²Histocompatibility Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil; ³Blood Bank, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Backgroud: The best choice to treat AMR is not supported by several evidences, and recently the interest in drugs as Bortezomib has improved. Aim: Evaluted…
2016 American Transplant Congress
Impact of Angiotensin II Type I Receptor Antibody Positivity in Highly-HLA Sensitized (HS) Patients Transplanted After Desensitization (DES).
A. Vo,¹ C. Boutsicaris,¹ X. Zhang,² N. Reinsmoen,² J. Choi,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; ²HLA Laboratory, Cedars-Sinai Medical Center, LA, CA.
Introduction: Angiotensin II type I receptor antibody (AT1R Ab) is a target for non-HLA antibodies. AT1R ab exert direct effects on endothelial and vascular smooth…
2016 American Transplant Congress
C1q Assays Are Not Associated with Clinical or Serologic Endpoints.
A. Gilbert,¹ M. Zaheer,¹ O. Timofeeva,² M. Awwad,² D. Li,² S. Rosen-Bronson,² B. Javaid,¹ M. Grafals,¹ J. Verbesey,¹ P. Abrams,¹ M. Cooper.¹
¹Medicine, MedStar Georgetown Transplant Institute, Washington, DC; ²Pathology, MedStar Georgetown Transplant Institute, Washington, DC; ³Surgery, MedStar Georgetown Transplant Institute, Washington, DC.
PURPOSE: The c1q assay has been proposed as a potential adjunct to standard donor specific antibody (DSA) testing designed to improve the specificity to identify…
2016 American Transplant Congress
Impact of C3d and C1q-Binding DSA Detected Long-Term After Kidney Transplantation.
M. Crespo,^1,2 D. Redondo,^1,2 C. Garcia,³ J. Gimeno,⁴ M. Perez,^1,2 M. Mir,¹ J. Hernandez,³ J. Yelamos,² A. Faura,^1,2 J. Pascual.^1,2
¹Nephrology and Transplant, Hospital del Mar, Barcelona, Spain; ²Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain; ³Catalunya Reference Laboratory, Barcelona, Spain; ⁴Pathology, Hospital del Mar, Barcelona, Spain.
HLA DSA detected after kidney transplantation(KT) correlate with outcome, but not all are equal and produce the same functional consequences. Early complement-binding DSA were asssociated…
2016 American Transplant Congress
Outcomes of Second Kidney Transplantation Compared Primary Transplantation According to Donor Specific Antibody.
J. Lee,^1,2 K. Lee,¹ J. Lee,¹ S. Song,¹ J. Lee,¹ S.-K. Kwon,¹ D. Joo,^1,2 K. Huh,^1,2 M. Kim,^1,2 S. Kim,^1,2 Y. Kim.^1,2
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; ²The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Background:Re-transplantation is associated with an improved overall survival of patients with a failed renal allograft. Some studies showed the outcomes of retransplantation are than those…