Abstracts Archive - Page 1247 of 1683 - ATC Abstracts

2016 American Transplant Congress
An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.
S. Sendil,¹ G. Braileanu,¹ W. Sun,¹ W. Hassanein,¹ D. Parsell,¹ H. Crum,² L. Burdorf,¹ R. Pierson,¹ A. Azimzadeh.¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ²VA Medical Center, Baltimore, MD.
Aim: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion; its mechanism remains poorly understood. In the context of a regimen…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
C1-Inhibitor Abrogated Ischemia/Reperfusion (I/R) Induced Inflammaging by Inhibiting Senescence-Associated Secretory Phenotype (SASP) in Tubular Epithelial Cells (TEC).
G. Castellano,¹ R. Franzin,¹ A. Stasi,¹ C. Divella,¹ M. Gigante,¹ S. Simone,¹ A. Intini,¹ A. Picerno,¹ P. Pontrelli,¹ A. Crovace,¹ M. Battaglia,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy; ²Pharming Technologies, Leiden, Netherlands; ³Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Inflammaging is a pathogenic process usually associated with chronic kidney disease such as diabetic nephropathy where TEC cells have a diminished regenerative potential and develop…
2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; ³Canadian National Transplant Research Program, CNTRP, Canada.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
2016 American Transplant Congress
Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.
A. Zarrinpar,¹ T. Palumbo,¹ K. Nakamura,¹ C. Lassman,² R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
2016 American Transplant Congress
Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).
B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…
2016 American Transplant Congress
Evolution of Donor Nephrectomy: Long-Term Outcomes with Four Different Techniques Between 1963 and 2014 at a Single Institution.
O. Serrano,¹ A. Bangdiwala,² D. Vock,³ E. Minja,¹ A. Pugalendhi,¹ K. Yadav,¹ V. Kirchner,¹ W. Payne,¹ T. Dunn,¹ S. Chinnakotla,¹ E. Finger,¹ T. Pruett,¹ A. Matas,¹ R. Kandaswamy.¹
¹Surgery, Univ. of Minnesota, Minneapolis, MN; ²Biostatistics and Bioinformatics Core, Masonic Cancer Center, Minneapolis, MN; ³Biostatistics, Univ. of Minnesota, Minneapolis, MN.
PURPOSE: The development of minimally-invasive approaches to donor nephrectomy (DN) has been primarily driven by the potential advantages it presents the donor. Questions remain over…
2016 American Transplant Congress
Characterization of Vascular Lesions in Living Donor Renal Transplant Implant Biopsies.
F. Tinney Jr,¹ L. Yessayan,² M. Abouljoud,³ A. Patel.³
¹Wayne State University School of Medicine, Detroit, MI; ²Department of Nephrology, Henry Ford Hospital, Detroit, MI; ³Transplant Institute, Henry Ford Hospital, Detroit, MI.
INTRODUCTION: Nephrosclerosis is often associated with pathological injury to kidneys resulting from chronic high blood pressure and/or aging, and may predict the progression of decline…
2016 American Transplant Congress
Health Insurance Trends in United States Living Kidney Donors.
J. Rodrigue,^1,2 A. Fleishman.¹
¹Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, Harvard Medical School, Boston, MA.
The aim of this study was to examine health insurance trends in living kidney donors (LKDs) in the United States and their association with donor…
2016 American Transplant Congress
The Impact of Pre-Donation eGFR on Recipient Outcomes, as a Function of Donor Age.
J. Gill,¹ J. Dong,² O. Djurdjev,² J. Lesage,¹ C. Rose,¹ J. Gill.¹
¹Medicine, UBC, Vancouver, BC, Canada; ²BC Renal Agency, Vancouver, BC, Canada.
Transplantation from older living kidney donors is increasing. Studies have shown that living donor age only modestly impacts recipient outcomes, but the kidney function of…