Abstracts Archive - Page 1245 of 1683 - ATC Abstracts

2016 American Transplant Congress
Stem Cell-Mediated Regeneration of Ischemically Damaged Renal Allografts During Ex Vivo Warm Perfusion.
L. Brasile,¹ N. Henry,¹ B. Stubenitsky.²
¹BREONICS Inc., Watervliet, NY; ²Plastic Surgery, University of Utrecht, Utrecht, Netherlands.
Our goal is to address an unmet medical need by providing more kidneys for transplant. We asked 2 questions: Could a tissue-engineering platform be used…
2016 American Transplant Congress
Ex Vivo Perfusion of Porcine Forelimbs to Prolong Allowable Ischemia Time.
N. Krezdorn,¹ M. Kueckelhaus,² A. Dermietzel,² M. Alhefzi,¹ M. Aycart,¹ S. Fischer,³ T.-S. Win,¹ H. Kiwanuka,¹ E. Bueno,¹ B. Pomahac.¹
¹Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston; ²Department of Plastic Surgery, Burn Center, Sarcoma Reference Center, BG University Hospital Bergmannsheil, Bochum, Germany; ³Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany.
PurposeSuccessful replantation in patients suffering from traumatic amputation of one or more extremities is limited by the muscle ischemia time of 4-6h, which also holds…
2016 American Transplant Congress
Creation of a Small Animal Model of Ex-Vivo Normothermic Perfusion (EVNP) for Treatment of Kidney Ischemia-Reperfusion (I/R) Injury.
Y. Smolin, I. Palma, C. Pivetti, S. Kabagambe, J. Woloszyn, Y. Chen, T. Boyer, I. Palma, J. Sageshima, C. Santhanakrishnan, R. Perez.
Department of Surgery, UC Davis Medical Center, Sacramento, CA.
Purpose: Recent studies have suggested that EVNP may be utilized to assess and repair marginal donor organs subjected to severe I/R injury. The lack of…
2016 American Transplant Congress
Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.
D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…
2016 American Transplant Congress
NecroX-7 Attenuates Ischemia-Reperfusion Renal Injury.
K. Lee,¹ Y. Ham,¹ J. Jeon,¹ Y. Chang,² S. Chung,¹ K. Na,¹ D. Choi.¹
¹Renal Division, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea; ²Internal Medicine, Daejeon Saint Mary Hospital, College of Medicine, Catholic University, Daejeon, Korea.
Introduction: Recently mitochondrial damage has been known to play a major role in various renal injury mechanisms including ischemia-reperfusion (IR) renal injury. Mitochondrial injury and…
2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…
2016 American Transplant Congress
Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.
T. Yagisawa, N. Kohei, D. Kish, R. Fairchild.
Dept. Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
Engagement of Toll-like receptors (TLR) by endogenous danger-associated molecular pattern ligands contributes to the intensity of tissue inflammation, including the inflammation generated during ischemia-reperfusion injury…
2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
2016 American Transplant Congress
Sphingosine-1 Phosphate Receptor 1 Agonist SEW2871 Ameliorates Hepatocellular Injury on Ischemic Reperfusion in Mice: A New Therapeutic Target.
T. Ito, N. Kuriyama, A. Matsuda, H. Kato, Y. Iizawa, Y. Murata, A. Tanemura, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.
Introduction: We had reported that activated protein C (APC) administration had cytoprotective effects on hepatic ischemic reperfusion (IR) injury in rat and mice models. Recent…