2016 American Transplant Congress
New Kidney Allocation System: Friend or Foe?
BACKGROUND The new kidney allocation (KAS) system was implemented 12/2014 to increase recipient life years gained annually and facilitate the transplantation of harder to match…2016 American Transplant Congress
The Simplified EPTS Score: Who Wins and Who Loses?
Cleveland Clinic, Cleveland, OH.
The New Kidney Allocation System includes provisions that candidates with EPTS score in the lowest 20% (indicating best expected survival) have access to the highest…2016 American Transplant Congress
Early Impact of the New Kidney Allocation System (KAS) in Highly Sensitized Patients.
University of Alabama at Birmingham, Birmingham, AL.
PurposeHighly sensitized (HS) patients, defined as a PRA of 99-100% are awarded additional priority points in the new KAS instituted December 2014. We evaluated the…2016 American Transplant Congress
Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…2016 American Transplant Congress
Alterations in Central Carbohydrate Metabolism in Porcine Liver Allografts Preserved with a Subnormothermic Machine Perfusion (SNMP) System.
University of Pittsburgh, Pittsburgh.
Introduction: Combination of reduced temperature and oxygenation via machine perfusion during liver allograft preservation has the potential to induce profound effects on hepatocyte bioenergetics and…2016 American Transplant Congress
Liver Graft Rejuvenation Prior to Transplantation: A Bench-to-Bedside Approach.
1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
To address the shortage of organs for transplantation many use “marginal” livers, which are particularly susceptible to ischemia-reperfusion injury (IRI). We have taken a two-pronged…2016 American Transplant Congress
Mesenchymal Stem Cells Reprogram Macrophage Polarization and Attenuate Liver Ischemia and Reperfusion Injury by Regulating Notch/Cox2/PGE2 Signaling Pathway.
Background and aims: Mesenchymal stem cells (MSCs) have been shown an immune modulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown…2016 American Transplant Congress
Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…2016 American Transplant Congress
Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.
Background: Kidneys from all donor sources are highly sensitive to ischemia-reperfusion injury (IRI). However, grafts donated after cardiac death (DCD) sustain an increased incidence of…2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
American Transplant Congress abstracts