ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    High Tacrolimus Dose Requirements at Month 6 Are Associated with Inferior Graft Function in Renal Transplant Patients.

    O. Rissling, S. Brakemeier, L. Lehner, F. Halleck, O. Staeck, D. Schmidt, K. Budde.

    Department of Nephrology, Charité Universitaetsmedizin, Berlin, Germany.

    Introduction: Tacrolimus (Tac), the mainstay of immunosuppression in renal transplant (tx) patients (pts) is known for drug induced nephrotoxicity, which may limit graft survival.Methods: In…
  • 2016 American Transplant Congress

    Evaluation of an Early Steroid Withdrawal Maintenance Regimen in African American Renal Transplant Recipients.

    S. Gabardi, M. Kim, R. Alsheikh, K. Townsend, A. Chandraker.

    Brigham and Women's Hospital, Boston, MA.

    Introduction: Outcomes in African American (AA) transplant recipients are inferior to other ethnic groups. This population also has an accelerated decline in graft function after…
  • 2016 American Transplant Congress

    Advantages of Computerized Dosing Strategy in Tacrolimus Treatment of Renal Transplant Patients.

    S.-Y. Kim,1 S. Cho,1 M.-J. Cho,1 C. Lee,1 A. Han,1 C. Choi,1 S. Ahn,1 S.-I. Min,1 S.-K. Min,1 M. Park,2 I. Jung,3 S. Kim,4 J. Ha.1,2

    1Department of Surgery, Seoul National University Hospital, Seoul, Korea; 2Korea Organ Donation Agency, Seoul, Korea; 3Department of surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea; 4Department of Surgery, Myoungji Hospital, Goyang-si, Korea.

    Purpose: Tacrolimus (Tac) is widely used in immunosuppression for kidney transplant (KT) patients. Despite this, it is still difficult for expert physicians to achieve and…
  • 2016 American Transplant Congress

    A Weighted Approach to Composite Efficacy Analysis in Kidney Transplantation.

    B. Kaplan, K. MaCague, D. Patel, F. Vincenti.

    Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.

    The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior to CellCept® (mycophenolate mofetil…
  • 2016 American Transplant Congress

    Everolimus and Low Dose Cyclosporine Immunosuppressive Regimen and Development of Anti HLA Donor Specific Antibodies.

    E. Minetti,1 L. Di Maria,1 L. Caroti,1 E. Buti,2 P. Carta.1

    1Nephrology unit, Careggi University Hospital, Florence, Italy; 2Nephrology Unit, Mayer Univerity Hospital, Florence, Italy.

    Few data are available on the rate of de novo anti-HLA donor specific antibodies (DSA) with the use of everolimus in kidney transplant recipients.MaterialsWe selected…
  • 2016 American Transplant Congress

    Impact of Ethnicity on Tacrolimus Trough/Dose Ratios Following Solid Organ Transplantation.

    A. Santeusanio, A. Owusu-Obeng, J. Jeff.

    Mount Sinai Hospital, New York.

    Objective: to assess tacrolimus dosing requirements based upon ethnicity in order to help guide future decisions regarding dosage initiation and titration among Hispanic and African…
  • 2016 American Transplant Congress

    Pediatric Patients Benifit from Steroids Free Regimen After Kidney Transplantation: A Meta-Analysis.

    R. Deng, H. Zhang, Y. Zheng, L. Liu, C. Wang.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

    Objective: To evaluate the effect of steroids avoidance or withdrawal (SAW) protocol on pediatric recipients by performing a meta-analysis of randomized controlled trials (RCTs).Method: A…
  • 2016 American Transplant Congress

    Comparison of Transplant Outcomes for Low-Dose and Standard-Dose Tacrolimus in Kidney Transplant Recipients.

    J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, E. Kwon, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim, C.-D. Kim.

    Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

    Objectives: There are few studies that compare the effect of different dose of tacrolimus after kidney transplantation. We investigated transplant outcome of low-dose and standard-dose…
  • 2016 American Transplant Congress

    Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Kidney Recipients.

    C.-K. Oh,1 S.-J. Kim,2 K. Huh,3 S. Kim,4 H. Cho,5 S. Lee.6

    1Surgery, Ajou University School of Medicine, Suwon, Republic of Korea; 2Surgery, Samsung Medical Center, Seoul, Republic of Korea; 3Surgery, Yonsei University Health System, Seoul, Republic of Korea; 4Surgery, CHA University School of Medicine, Pocheon, Republic of Korea; 5Surgery, Ulsan University Hospital, Ulsan, Republic of Korea; 6Surgery, Ajou University School of Medicine, Suwon, Republic of Korea.

    Background. Many of immunosuppressive drugs have been prescribed as twice-daily dosing. Simplified once-daily dosing of the entire drug regimen can enable patients to improve treatment…
  • 2016 American Transplant Congress

    The BEST Trial: A Prospective Randomized Trial of Belatacept-Based, CNI- and Corticosteroid-Free Immunosuppression.

    E. Woodle,1 D. Kaufman,2 A. Shields,1 J. Leone,3 A. Matas,4 A. Wiseman,5 P. Thielke,6 R. Alloway.1

    1U Cincinnati, Cinci; 2U Wisconsin, Madison; 3Tampa General, Tampa; 4U Minnesota, Minn; 5U Colorado, Denver; 6U Illinois Chicago, Chic.

    Efficacy of CNI- and corticosteroid-free immunosuppressive regimens has not been demonstrated in large, multicenter trials. BEST (Belatacept-based Early Steroid Withdrawal Trial) (NCT 01729494) compares 2…
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