Abstracts Archive - Page 12 of 1683 - ATC Abstracts

2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
2022 American Transplant Congress
Evaluation of Donor Exclusion Criteria in Living Donor Liver Transplantation: A Single-Center Experience
D. Daskalaki, M. E. Akoad, J. Kim, C. J. Simon, Y. Cheah
Hepatobiliary Surgery and Liver Transplantation, Lahey Hospital and Medical Center, Burlington, MA
*Purpose: Liver donation is fundamental in increasing the pool of available grafts. Careful evaluation of each donor ensures the best outcomes for the recipient and…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…
2022 American Transplant Congress
Steatosis Following Liver Transplantation for Nonalcoholic Steatohepatitis is Associated with a Higher Rate of Cardiovascular Complications
W. Alhamoudi¹, S. Alqahtani², K. Bzeizi², A. Albenmousa², Y. Saleh², D. Broering², S. Alghamdi²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplantation, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
*Purpose: Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) worldwide. Objectives: to evaluate the prevalence of…
2022 American Transplant Congress
Size to Fit: A Simple Formula to Predict Donor Liver Weight in Deceased Donor Liver Transplant
A. Mohamed¹, J. Cui², T. Kitajima¹, T. Shamaa¹, T. Ivanics¹, I. Godana³, A. Yorks², S. Shimada¹, B. Madek¹, M. Rizzari¹, A. Yoshida¹, M. Abouljoud¹, S. Nagai¹, K. Collins¹
¹Henry Ford Transplant Institute, Detroit, MI, ²Wayne State University School of Medicine, Detroit, MI, ³General Surgery, McLaren, Lansing, MI
*Purpose: Estimated donor liver volume (DLV) prediction equations are widely published. However, they often are complex and underpredict DLV, particularly in non-ideal body weight donors.…
2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
Y. Shim¹, R. Fan², N. Dvorina², K. McCrae¹, B. William²
¹Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, ²Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
2022 American Transplant Congress
Results Of The Ctot19 Trial: Infliximab (IFX) Induction Does Not Impact 2-year Outcomes In Deceased Donor Kidney Transplant Recipients
P. Heeger¹, B. Armstrong², T. Alhamad³, D. Brennan⁴, J. Bromberg⁵, S. Bunnapradist⁶, S. Chandran⁷, R. Fairchild⁸, D. Foley⁹, R. Formica¹⁰, I. W. Gibson¹¹, D. Hricik¹², K. Kesler², R. B. Mannon¹³, M. Menon¹⁰, K. Newell¹⁴, P. Nickerson¹¹, J. Odim¹⁵, E. Poggio⁸, R. Sung¹⁶, R. Shapiro¹, K. Tinckam¹⁷, F. Vincenti⁷
¹Mount Sinai, New York, NY, ²Rho, Durham, NC, ³Washington U, Saint Louis, MO, ⁴Johns Hopkins, Baltimore, MD, ⁵U Maryland, Baltimore, MD, ⁶UCLA, Los Angeles, CA, ⁷UCSF, San Francisco, CA, ⁸Cleveland Clinic, Cleveland, OH, ⁹U Wisconsin, Madison, WI, ¹⁰Yale, New Haven, CT, ¹¹U Manitoba, Winnipeg, MB, Canada, ¹²U Hosp Case, Cleveland, OH, ¹³U Nebraska, Omaha, NE, ¹⁴Emory, Atlanta, GA, ¹⁵NIAID NIH, Rockville, MD, ¹⁶U Michigan, Ann Arbor, MI, ¹⁷U Hlth Network, Toronto, ON, Canada
*Purpose: Ischemia-reperfusion (IR) of a kidney transplant (KTx) up-regulates tumor necrosis factor alpha (TNF) production within the allograft. IR-induced TNF amplifies post-KTx allograft inflammation and…
2022 American Transplant Congress
Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model
M. Ma¹, P. Chhabra¹, G. Laurie², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…
2022 American Transplant Congress
Impact of Donor-to-Recipient Body Surface Area Ratio on Graft Survival and Mortality Following Deceased Donor Liver Transplants
S. Radomski, L. Zeiser, A. Massie, S. Ottmann, D. Segev, E. King
Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: The impact of size mismatch on graft survival in living donor liver transplant is well established but is not a common concern in deceased…