Abstracts Archive - Page 1185 of 1683 - ATC Abstracts

2016 American Transplant Congress
Planning Genitourinary Vascularized Composite Allotransplantation: A Pre-Operative Imaging Protocol.
I. Schol, T. Drijkoningen, G. Choy, R. Liu, C. Tanrikut, P. Holzer, D. Ko, C. Cetrulo.
Massachusetts General Hospital, Boston, MA.
Study purpose: To define the ideal pre-operative imaging protocol necessary for proper planning of a genitourinary vascularised composite allotransplantation (GUVCA) procedure.Methods: The multidisciplinary GUVCA team…
2016 American Transplant Congress
Vascular Composite Allotransplantation Collaborative Initiative Biobank: Bringing the Power Back to Research.
J. Cheeseman, M.-B. Joshi, F. Leopardi, R. Osborne, D. Conlon, L. Stempora, M. Song, L. Cendales.
Surgery, Duke University, Durham, NC.
Refining Vascular Composite Allotransplantation (VCA) into a useful therapeutic option for patients in need of tissue reconstruction depends on the availability of biological specimens and…
2016 American Transplant Congress
Absence of Acute Allograft Rejection in the Early Post Operative Period in a Full Face VCA Recipient with a Positive B-Cell Flow Cytometric Crossmatch Utilizing an Induction Immunosuppression Regimen Including Anti-thymocyte and Anti-CD20 Agents.
B. Gelb,³ M. Plana,¹ D. Dadhania,² M. Suthanthiran,² J. Diaz-Siso,¹ E. Rogriguez.¹
¹Plastic and Reconstructive Surgery, NYU Langone, New York; ²Rogosin Institute, New York; ³Transplant Surgery, NYU Langone, New York.
Background: The presence of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) convey increased risk of allograft rejection. Patients suffering full-thickness burns to the face…
2016 American Transplant Congress
Radiosensitive Cell Population Prolongs Graft Survival of Vascularized Composite Allografts in Non-Human Primates.
M. Uluer, J. Woodall, W. Hassanein, U. Drhu, B. Bojovic, A. Nam, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD.
Background: Vascularized composite allografts (VCA) containing vascularized bone marrow (VBM) prolong graft survival. To help elucidate this protective immunomodulatory effect, we irradiated donor facial VCA…
2016 American Transplant Congress
Peritransplant Costimulation Blockade Combined with a Short-Course of Rapamycin Prevents Rejection of Vascularized Composite Allografts.
B. Oh, G. Furtmüller, M. Fryer, P. Akre, D. Cooney, W. Lee, G. Raimondi, G. Brandacher.
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss. Routine clinical application, however, is hampered by the toxicity of long-term maintenance immunosuppression.…
2016 American Transplant Congress
Assessing the Induction of Tolerance to Vascularized Composite Allotransplantation in Miniature Swine.
J. Walch, J. Alonso-Escalante, H. Wang, B. Oh, M. Iglesias, A. Lee, G. Brandacher, G. Raimondi.
Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD.
Purpose: Miniature swine is a pre-clinical large animal model well suited to validate protocols of tolerance induction to vascularized composite allotransplantation (VCA). However, tools to…
2016 American Transplant Congress
Tolerance Induction in Vascularized Composite Allotransplantation with Peri-Transplant Combined Costimulation Blockade.
B. Oh,¹ G. Furtmüller,¹ M. Fryer,¹ J. Grahammer,² S. Schneeberger,² D. Cooney,¹ G. Raimondi,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
[Background] Vascularized composite allotransplantation (VCA) is an emerging new era in transplant medicine and has become a valid therapeutic option after devastating tissue loss, such…
2016 American Transplant Congress
Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.
L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.
CHOP & UPenn, Philadelphia.
Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…
2016 American Transplant Congress
The In Vivo Non-Invasive Long-Term Functional Assessment of Neuronal Regeneration in Vascularized Composite Allotransplantation.
C.-J. Wen,^1,2 C.-H. Lin,¹ S.-L. Peng,^3,4 F.-N. Wang,³ L.-Y. Huang,³ H.-Y. Cheng,¹ H.-H. Hsu,¹ X.-T. Huang,¹ C.-H. Lin,¹ F.-C. Wei.¹
¹Center for Vascularized Composite Allotransplantation, Chang Gung Medical Foundation, Taoyuan, Taiwan; ²Department of Medicine, Chang Gung University, Taoyuan, Taiwan; ³Department of Biomedical Engineering and Environmental Sciences, Tsing Hua University, Hsinchu, Taiwan; ⁴Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
The neuronal regeneration is a key issue of vascularized composite allotransplantation (VCA).As for the generally used functional observations, behavior testing or invasive functional inspection (e.g.…
2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
L. Cendales,¹ M. Levine,² S. Bartlett,³ J. Cheeseman,¹ C. Drachenberg,³ W. Hancock,⁴ M. Joshi,¹ A. Kirk,¹ F. Leoopardi,¹ S. Levin,² M. Uluer,³ A. Selim,⁵ M. Song,¹ W. Twaddell,³ L. Wang,⁴ Z. Wang,² R. Barth.³
¹Surgery, Duke University, Durham, NC; ²University of Pennsylvania, Philadelphia, PA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ⁵Pathology, Duke University, Durham, NC.
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…