Abstracts Archive - Page 1169 of 1683 - ATC Abstracts

2016 American Transplant Congress
Predonation Prescription Narcotic Use: A Novel Risk Factor for Readmission After Living Donor Nephrectomy.
K. Lentine,^1,7 D. Segev,^2,1 D. Axelrod,³ N. Lam,⁴ A. Garg,⁵ G. Hess,⁶ B. Kasiske,¹ D. Brennan,⁸ H. Randall,⁷ M. Schnitzler.^7,1
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Johns Hopkins, Baltimore; ³Dartmouth, Hanover; ⁴Univ Alberta, Alberta, Canada; ⁵Western Univ, London, Canada; ⁶Symphony Health, Pittsburgh; ⁷Saint Louis Univ, St. Louis.
Implications of narcotic use in living kidney donor (LKD) candidates for key outcomes, including readmission rates after nephrectomy, are unknown.We integrated 1) national Scientific Registry…
2016 American Transplant Congress
Kidney Structural Characteristics as Predictors of Long-Term Kidney Function in Living Kidney Donors.
J. Mathew,¹ A. Denic,¹ M. Alexander,² T. Vrtiska,³ H. Chakkera,⁴ S. Taler,¹ A. Rule.¹
¹Nephrology, Mayo Clinic, Rochester, MN; ²Pathology, Mayo Clinic, Rochester, MN; ³Radiology, Mayo Clinic, Rochester, MN; ⁴Nephrology, Mayo Clinic, Scottsdale, AZ.
PurposeKidney structural characteristics may be predictive of long-term living donor outcomes such as a lower estimated Glomerular Filtration Rate (eGFR).MethodsAs part of the Renal and…
2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
Molecular Assessment of Kidney Transplant Biopsies Performs Similarly in Medulla and Cortex.
K. Madill-Thomsen,¹ J. Reeve,¹ G. Bohmig,² F. Eskandary,² P. Halloran.^1,3
¹Alberta Transplant Applied Genomics Center, Edmonton, AB, Canada; ²Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ³Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
Histologic assessment of kidney biopsies is usually unable to interpret medulla, but molecular changes associated with rejection likely occur in both medulla and cortex. Analysis…
2016 American Transplant Congress
Malignancies Contribute to Presensitization with Alloreactive T-Cells in Kidney Transplant Recipients.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
Alloreactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute rejection in the initial period after kidney transplantation. Knowledge…
2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
E. Crespo,¹ S. Luque,¹ J. Cruzado,² E. Melilli,² J. Grinyo,² M. Lucia,¹ O. Bestard.²
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…
2016 American Transplant Congress
The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.
U. Khalid, P. Donato, L. Szabo, R. Chavez, E. Ablorsu, A. Asderakis.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…
2016 American Transplant Congress
Reversibility of Acute Kidney Rejection According to the Banff 2013 Classification: A Retrospective Cohort Study.
A. Poulin,¹ M. Dorais,² L. Sénécal,³ S. Colette,³ H. Cardinal.¹
¹CRCHUM, Montreal, QC, Canada; ²Statsciences, Montreal, QC, Canada; ³HMR, Montreal, QC, Canada.
Background: Vascular involvement of the allograft has classically been regarded as a poor prognostic factor in acute kidney graft rejection. Cell-mediated endarteritis often coexists with…
2016 American Transplant Congress
Molecular Profiles of Renal Allograft Rejection.
Z. Hajjiri, P. Finn, D. Perkins.
Internal Medicine/Renal Medicine, University of Illinois at Chicago, Chicago, Il.
Introduction: The gold standard for the diagnosis of allograft rejection is the Banff Classification, yet it shows substantial variability among pathologists. Using molecular signatures of…
2016 American Transplant Congress
A Non-Invasive Blood Transcriptional Assay, Ksort, Monitors Alloimmune Response in the Sailor Randomized Multicenter Trial.
J. Ekberg,¹ B. Jespersen,² K. Skov,² M. Sarwal,³ T. Sigdel,³ S. Hsieh,³ P. Lindner.¹
¹Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden; ²Nephrology, Skejby Hospital, Aarhus, Denmark; ³Surgery, University of California, San Francisco.
Non-invasive diagnosis and prediction of acute rejection (AR) is a critical unmet need. A In a randomized multicenter trial of 222 renal transplant recipients a…