ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Living Donor Kidney Transplant Outcomes Have Improved Over the Last Decade.

    A. Nishio Lucar, G. Vranic, D. Keith.

    Medicine, University of Virginia, Charlottesville, VA.

    Our group recently reported improved 6-month eGFR and long-term patient and allograft outcomes in deceased donor transplant over the last decade. Our goal was to…
  • 2016 American Transplant Congress

    Nondirected Kidney Donation – Donating More Than a Kidney.

    C. Jacobs,1 J. Wiseman,1 D. Berglund,1 D. Larson,1 C. Garvey,1 M. Vogues,1 S. Rein,1 O. Sanchez,1 C. Radecki Breitkopf,2 H. Ibrahim,1 A. Matas.1

    1U of MN, Mpls; 2Mayo Clinic, Rochester.

    Little is known about donation-related out-of-pocket costs incurred by NDD. For NDD, we studied: resources used to cover these costs; level of stress due to…
  • 2016 American Transplant Congress

    Association of Neighborhood Poverty and Living Donor Kidney Transplant Rates by Donor Relationship to Recipient.

    G. Vranic, A. Nishio Lucar, D. Keith.

    Medicine, University of Virginia, Charlottesville, VA.

    Background: Living donor (LD) kidney transplant is associated with increased access to transplant and improved patient and allograft outcomes. Despite the known benefits, LD rates…
  • 2016 American Transplant Congress

    Survival Advantage with Older Live Donor Compared to Standard Criteria Deceased Donor Kidney Transplantation in Older Recipients.

    P. Abrams, M. Cooper, J. Verbesey, R. Ghasemian, M. Grafals, A. Gilbert, J. Moore, J. Fenton, C. Cannon, J. Rapisurra, B. Javaid.

    MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC.

    Objective: Analyze post-transplant outcomes in older recipients of kidney transplants from older live donors compared to older recipients of standard criteria deceased donor kidney transplants.Methods:…
  • 2016 American Transplant Congress

    Relationship Between Mean Fluorescence Intensity and C1q/C3d-Fixing Capacities of Anti-HLA Antibodies.

    G. Claisse,1 L. Absi,2 E. Alamartine,1 N. Maillard,1 C. Mariat.1

    1Centre Hospitalier Universitaire - Hôpital Nord, Saint-Etienne, France; 2Laboratoire EFS Loire-Auvergne, Saint-Etienne, France.

    The capacity of anti-HLA antibodies (Abs) to activate complement is thought to be an informative property susceptible to facilitate outcome prediction. Two different tests, C1q-…
  • 2016 American Transplant Congress

    Fc Receptor Binding Assay for Functional Assessment of HLA Antibodies: Initial Clinical Validation.

    E. Woodle, A. Girnita.

    U of Cincinnati, Cincinnati.

    Functional assessment of HLA antibodies (Abs) has historically been limited to complement-based assays, which have known limitations. Moreover, HLA Abs mediate injury by complement-independent mechanisms,…
  • 2016 American Transplant Congress

    Blindspots in HLA Antibody Testing: Recognition Is First Step to Nirvana.

    A. Kher, P. Dorwal, V. Kher.

    Medanta-The Medicity, Gurgaon, Haryana, India.

    This study was conducted to assess population frequency of alleles missing from single antigen bead (SAB) panels & frequency of allelic antibodies (Abs).Methods: All positive…
  • 2016 American Transplant Congress

    An Improved Method for the Evaluation of Microvascular Inflammation in Renal Allograft Biopsies.

    M. Rooney,1 Z. Ping,2 D. Samarapungavan,3 R. Hennigar.4

    1Incyte Diagnostics, Spokane Valley, WA; 2Pathology, Beaumont Hospitals, Royal Oak, MI; 3Nephrology, Beaumont Hospitals, Royal Oak, MI; 4Nephropathology Associates, Little Rock, AR.

    Background: Microvascular inflammation (MVI), assessed as glomerulitis (g) + peritubular capillaritis (ptc), is associated with T cell mediated (CMR) and antibody mediated (AMR) allograft rejection.…
  • 2016 American Transplant Congress

    Blocking Fc Receptor in Flow Cytometric Crossmatch: Refining an Old Assay to Improve Patient Management.

    N. Brown, J. Wang, S. Marino.

    Pathology, University of Chicago, Chicago, IL.

    Introduction: The crossmatch assay is used to determine sensitization of solid organ transplant recipients to donor-expressed HLA molecules, a potential contraindication to transplant. Multicolor flow…
  • 2016 American Transplant Congress

    Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.

    C. Lefaucheur,1 L. Hidalgo,2 J. Reeve,2 D. Viglietti,1 C. Gosset,1 O. Aubert,3 C. Ulloa,3 C. Legendre,3 D. Glotz,1 P. Halloran,2 A. Loupy.3

    1Saint-Louis Hospital, Paris, France; 2University of Alberta, Edmonton, Canada; 3Necker Hospital, Paris, France.

    Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…
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