2017 American Transplant Congress
Pre-Transplant Recipient Transcriptomic Profile May Predict Delayed Graft Function (DGF) in Kidney Transplantation.
Background: DGF is associated with a reduced long-term graft survival. Ischemia-reperfusion damage and donors' features have been always considered as key pathogenic factors in this…2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Parallels Increases in Donor Specific Antibodies in Pediatric Kidney Transplant Recipients.
1Surgery, Stanford University, Palo Alto, CA; 2CareDx, Brisbane, CA
Introduction: Anti-HLA antibody screening is a critical component of post-kidney transplant surveillance. Existing protocols and treatment plans are not standard/consistent across institutions. As increasing numbers…2017 American Transplant Congress
Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection.
[Introduction and Objective] Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by simultaneous activation of NFκB and STATs (IL-17, TNFα, and…2017 American Transplant Congress
Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates.
Center for Transplant Science, Massachusetts General Hospital, Boston, MA
Background: We have previously reported donor specific expansion of regulatory T cells (Tregs) in nonhuman primate (NHP) recipients which achieved renal allograft tolerance after induction…2017 American Transplant Congress
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation.
Bronchiolitis obliterans syndrome (BOS) is the main manifestation of chronic lung allograft dysfunction responsible for the poor long-term outcome after lung transplantation. While physiopathological mechanisms…2017 American Transplant Congress
Life Confocal Imaging of Murine Liver Biopsies as Novel Tool to Assess Graft Viability Prior to Transplantation.
Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
Prolonged ischemia time due to organ procurement and transport are main contributors to a decrease in organ quality, which is further enhanced during reperfusion. This…2017 American Transplant Congress
Assessment of C4d Positive Biopsies with No Histological Evidence of Inflammation Using Nanostring nCounter Technology.
Deposition of C4d has been an established part of the Banff classification scheme for antibody mediated rejection (AbMR) since 2001. More recently, C4d negative AbMR…2017 American Transplant Congress
Refinement of an Old Faithful: A Standardized Flow Cytometry Approach to Measure Donor-Recipient Alloreactivity (a Pilot Study).
Purpose: Donor-specific antibody (DSA) and antibody (Ab)-mediated rejection are challenges in long-term outcomes and limit re-transplantation. Sensitizing events such as homografts in surgical procedures, assist…2017 American Transplant Congress
Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.
Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…
American Transplant Congress abstracts