2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…2017 American Transplant Congress
The Transcription Factor Batf and IRF1 Controls IL-10/IL-27 Expression in Dendritic Cells and Transplant Tolerance Induction.
Objective: To explore the effect of Batf and IRF1 on IL-10/IL-27 expression in DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT…2017 American Transplant Congress
Two Months Delayed Induction of Mixed Chimerism After Heart and Kidney Cotransplantation in Nonhuman Primates.
Background We have previously achieved transplant tolerance in cynomolgus recipients cotransplanted with heart and kidney by treating recipients with standard triple drug immunosuppression for 4…2017 American Transplant Congress
Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.
In this study, we investigated the mechanisms behind the activation induced cell death of human regulatory T cells (Tregs) that can explain their rapid loss…2017 American Transplant Congress
Increased Expression of Fibrillin-1 and Presence of Fibroblastic Reticular Cells in Treg-Rich Organized Lymphoid Structures (TOLS) of Accepted Kidney Allografts.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: Fibrillin-1, found in connective tissue, plays a role in the sequestration of TGF-b, and is produced by fibroblastic reticular cells (FRCs). It has been…2017 American Transplant Congress
IL-33 Enhances the Ability of Dendritic Cells to Expand Human Regulatory T Cells.
Introduction:The importance of increasing the number of regulatory T cells (Treg) relative to T effectors for the promotion of long-term experimental allograft survival/tolerance is well-established.…2017 American Transplant Congress
Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.
Purpose:In order to establish a protocol to generate large numbers of human alloantigen-reactive regulatory T cells (arTreg) with potent allospecific suppressive capacity for therapeutic application,…2017 American Transplant Congress
Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL
Background: Cell-based therapies represent a new promising strategy for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…2017 American Transplant Congress
Aryl Hydrocarbon Receptor Regulates Myeloid Derived Suppressor Cells by Activating the ERK Signaling in a Murine Cardiac Transplantation Model.
There is a growing evidence that Myeloid-derived suppressor cells (MDSCs) have a crucial role in organ transplantation; however, the detail condition where MDSCs are sufficiently…2017 American Transplant Congress
Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Non-Human Primates.
Mixed hematopoietic chimerism is a promising approach to achieving transplantation tolerance. Transient mixed chimerism leads to renal allograft tolerance in about 70% of cynomolgus macaques…
American Transplant Congress abstracts