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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    The Impact of Early Graft Infiltrating TCF-1LowPD-1HighCD8+ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model

    T. Ota1, R. Goto1, T. Harada1, Y. Ganchiku1, M. Zaitsu1, A. Forgioni1, N. Kawamura2, M. Watanabe2, M. Fukai1, T. Shimamura3, A. Taketomi1

    1Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, 2Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, 3Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan

    *Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…
  • 2022 American Transplant Congress

    Deceased Donor Kidney Transplantation from Donors with Acute Kidney Injury: Realities and Costs

    S. Iskhagi1, R. Shahbazov1, A. Ball1, S. Loerzel1, E. Shaban2, B. Gallay2, R. Hod Dvorai3, J. Leggat2, M. Hanlon1, R. Saidi1

    1Department of Surgery, Division of Transplantation, SUNY Upstate Medical University, Syracuse, NY, 2Department of Medicine, Division of Nephrology, SUNY Upstate Medical University, Syracuse, NY, 3Department of Pathology and Laboratory Medicine, SUNY Upstate Medical University, Syracuse, NY

    *Purpose: The use of kidneys from deceased donors with acute kidney injury (AKI) is one of the options to expand donor pool. Several studied have…
  • 2022 American Transplant Congress

    A Successful Expansion of Donor Liver Supply is Feasible with the Selective Use of Older DCD Livers

    M. Finotti, M. Rosenzweig, A. Wall, S. H. Lee, A. Gupta, J. Bayer, H. Fernandez, N. Onaca, R. Ruiz, G. Testa, G. J. McKenna

    Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX

    *Purpose: DCD are a key way to expand the donor pool, yet many centers are hesitant about using anything but the most favorable DCD allografts,…
  • 2022 American Transplant Congress

    Kinetics and Durability of a Third Dose of Sars-cov-2 Vaccination Among Solid Organ Transplant Recipients

    T. P. Chiang, J. Alejo, J. Mitchell, A. Abedon, L. Zeizer, J. Kim, L. Thomas, D. Segev, W. Werbel, A. Massie

    Johns Hopkins University, Baltimore, MD

    *Purpose: Understanding the dynamics of antibody response to a third dose (D3) of anti-SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) is important to inform…
  • 2022 American Transplant Congress

    Deceased Donor Organ Flush with Similar Volumes of HTK and UW at a Single U.S. Organ Procurement Organization: Adult and Pediatric Data

    A. E. Mangus1, C. Kubal2, B. Ekser3, P. Mihaylov4, A. J. Lutz1, J. Fridell5, R. Mangus6

    1Indiana University Purdue University of Indianapolis, Indianapolis, IN, 2Indiana University Hospital, Indianapolis, IN, 3Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, 4Indiana Univ School of Medicine, Indianapolis, IN, 5Indiana University School of Medicine, Indianapolis, IN, 6Indiana University, Indianapolis, IN

    *Purpose: Histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) solutions are the two primary solid-organ preservation solutions used in the United States (>95%), but flush volumes…
  • 2022 American Transplant Congress

    Center Variation is the Major Driver of Geographic Disparities in Access to Kidney Transplants Among Waitlisted Candidates

    D. Stewart, A. Robinson, A. Wilk, D. Klassen

    United Network for Organ Sharing, Richmond, VA

    *Purpose: The OPTN’s monitoring of equity in access to deceased donor kidney (KI) transplants (tx) among waitlisted candidates has consistently found service area (DSA) of…
  • 2022 American Transplant Congress

    Single Center Experience with Acute Kidney Injury Deceased Donor Kidneys from Marginal Donors

    B. K. Sharda, M. Garner, A. Farney, G. Orlando, C. Jay, J. Rogers, A. Daniel, A. Gutierrez, N. Sakhovskaya, R. Stratta

    Atrium Health Wake Forest Baptist Medical Center, Winston Salem, NC

    *Purpose: Many centers will selectively transplant kidneys from standard criteria donors (SCD) with terminal acute kidney injury (AKI). However, there is limited experience with transplanting…
  • 2022 American Transplant Congress

    ESRD is Increasing Faster After Living Kidney Donation Than it Does in the Unselected US Population: A New Risk Metric?

    R. W. Steiner

    UCSD School of Medicine, San Diego, San Diego, CA

    *Purpose: ESRD rates increase exponentially both after kidney donation and as the US population ages. Increases in ESRD rates from the first to the second…
  • 2022 American Transplant Congress

    Poor Prognosis of Proliferative Glomerulonephritis with Monoclonal IgG Deposits in Renal Allografts: A Retrospective Multicenter Study from China

    Q. Wu1, D. Liang1, X. Ni1, T. Song2, X. Wu3, M. Zhang1, J. Chen1, D. Cheng1, W. Jiqiu1

    1National Clinical Research Center of Kidney Diseases, Jinling Hospital,Nanjing University Jinling School of Medicine, Nanjing, China, 2Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, 3Department of Urology, Henan Provincial People's Hospital; Zhengzhou University People's Hospital, Zhengzhou, China

    *Purpose: To analyze the clinicopathological characteristics, treatment efficacy and prognosis of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) in renal allografts from multi-centers in China.*Methods:…
  • 2022 American Transplant Congress

    Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates

    A. K. Singh1, C. Goerlich1, T. Zhang1, I. Tatarov1, P. Odonkor1, E. Strauss1, B. Williams1, B. Lewis1, A. Hershfeld1, F. Sentz1, D. Ayares2, D. Kaczorowski1, B. Griffith1, M. Mohiuddin1

    1Department of Surgery, University of Maryland, Baltimore, MD, 2Revivicor Inc, Blacksburg, WV

    *Purpose: Cardiac xenotransplantation (CXTx) is proposed as an alternate treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically engineered (GE) pig…
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