Abstracts Archive - Page 1107 of 1683 - ATC Abstracts

2017 American Transplant Congress
DC-SIGN Functionalized Porous Silicon Nanoparticles Targeting to Human and Non-Human Primate Dendritic Cells.
S. Stead,¹ S. Kireta,² S. McInnes,³ P. Rose,¹ S. Jesudason,^1,2 S. Grey,⁴ D. Rojas-Canales,² R. Carroll,^1,2 N. Voelcker,⁴ P. Coates.^1,2
¹Medicine, University of Adelaide, Adelaide, Australia; ²Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia; ³ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Adelaide, Australia; ⁴Transplantation Immunology, Garven Institute of Medical Research, Sydney, Australia
Porous silicon (pSi) nanoparticles, modified to specifically target DC, provide a novel platform to carry and deliver immunosuppressive drugs. The aim was to conjugate DC-SIGN…
2017 American Transplant Congress
Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.
J. Meyer,^1,2 E. Perroud,² P. Fontana,^3,4 K. Sadoul,⁵ P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2
¹Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ²Unit of Surgical Research, University of Geneva, Geneva, Switzerland; ³Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; ⁴Geneva Platelet Group, University of Geneva, Geneva, Switzerland; ⁵Institute for Advanced Biosciences, Inserm U1209, Grenoble, France
Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
2017 American Transplant Congress
CD16+ Monocytes and Skewed Macrophage Polarization Towards M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
T. van den Bosch,¹ K. Caliskan,² M. Kraaij,¹ A. Constantinescu,² O. Manintveld,² P. Leenen,³ J. von der Thüsen,⁴ M. Clahsen-van Groningen,⁴ C. Baan,¹ A. Rowshani.¹
¹Internal Medicine and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands; ³Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Pathology, Erasmus University Medical Center, Rotterdam, Netherlands
Purpose: During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is…
2017 American Transplant Congress
M1 Macrophage-Induced Loss of KLF15 Promotes Chronic Podocyte Injury.
S. Han,^1,2 Y. Kim,¹ S. Lee,¹ H. Lee,^1,2 R.-H. Cha,² J. Lee,^1,2 J. Lee,² D. Kim,^1,2 Y. Kim,^1,2 S. Yang.^1,2
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea
Background: Krüppel-like factor 15 (KLF15), kidney-enriched transcription factor, is known to participate in the differentiation of podocyte. However, the implication of KLF15 in chronic podocyte…
2017 American Transplant Congress
Toll-Like Receptor 4-Dependent CCAAT-Enhancer-Binding Protein Homologous Protein Activation Induces Hepatocellular Cell Death in Liver Ischemia and Reperfusion Injury.
H. Zhou,¹ Z. Rao,² H. Wang,¹ X. Wang,¹ L. Lu.¹
¹Department of Liver Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Critical role of Toll-like receptor 4(TLR4) and endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the relationship between…
2017 American Transplant Congress
A Novel MyD88 Inhibitor Attenuates Allograft Rejection in Heterotopic Tracheal Transplantation in Mice.
M. Yang, X. Zhang, G. Chen, Z.-C. Ding, Y. Miao, Y. Yang, P. Zhou.
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technolog; Key Lab of Ministry of Education & Ministry of Health of China, Wuhan, Hubei, China
Background: Obstructive bronchiolitis (OB) characterized by chronic rejection, is the main complication after lung transplantation which limits the long-term survival of the recipients. Innate immune…
2017 American Transplant Congress
The Beneficial Effects of mTOR Inhibitors on Liver Resident Natural Killer Cells.
J. Saparbay, Y. Tanaka, T. Yano, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Background) The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
2017 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney Is Critical for Resistance to Candida albicans Infections.
J. Lee,^1,4 V. Tran,³ H. Kim,¹ B. Kwon,^1,3 K. Park,^1,4 H. Cho.^1,2
¹Biomedical Research Center, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²Department of Surgery, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea; ³School of Biological Sciences, University of Ulsan, Ulsan, South Korea, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea
We previously showed that CCR5 mediates recruitment of NK cells to the kidney after renal ischemia and reperfusion, which in turn induce the production of…
2017 American Transplant Congress
Histone Methyltransferase EZH2 Was Involved in the Mechanism of let-7e Inhibition of TNF-α Expression.
J. Huang,^1,2,3 Y. Zhang,^1,2,3 Q. Zhang,^1,2,3 L. Gui,^1,2,3 Y. Cai,^1,2,3 X. Deng.^1,2,3
¹Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ³Institute of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Inflammatory cytokines, such as TNF-α, play important roles in transplantation and infection. The expression of these inflammatory factors can be regulated by many kinds of…
2017 American Transplant Congress
Pregnancy Outcomes in Female Kidney Transplant Recipients Using Assisted Fertility Methods.
L. Coscia,¹ D. Armenti,¹ S. Constantinescu,^1,2 M. Moritz.^1,3,4
¹Transplant Pregnancy Registry, Gift of Life Institute, Philadelphia, PA; ²Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA; ⁴Morsani College of Medicine, USF, Tampa, FL
The purpose of this study was to analyze pregnancy and transplant outcomes in female kidney recipients who used fertility medications alone (FM), intrauterine insemination (IUI),…