Abstracts Archive - Page 102 of 1683 - ATC Abstracts

2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
E. S. Szuter¹, T. Yokose¹, M. T. Guinn¹, J. Ge², I. Rosales³, B. Kwon⁴, P. S. Russell¹, A. Cuenca², D. Kreisel⁵, P. Sage⁶, J. C. Madsen¹, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁴Harvard College, Cambridge, MA, ⁵Department of Surgery, Washington University, St. Louis, MO, ⁶Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
2022 American Transplant Congress
Pegloticase Use in Renal Transplant Recipients with Gout: Findings from an Insurance Claims Database Study
C. A. Shadur¹, B. Marder², C. Vesel², B. LaMoreaux²
¹Iowa Kidney Physicians, Des Moines, IA, ²Horizon Therapeutics plc, Deerfield, IL
*Purpose: Kidney transplant (KT) recipients have high gout incidence due to reduced eGFR and medication use associated with hyperuricemia.1 Oral urate-lowering therapies in KT patients…
2022 American Transplant Congress
Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients
S. Shaikh¹, I. Hasan¹, N. Kaur²
¹Keck Medicine of USC, Los Angeles, CA, ²Keck School of Medicine, Los Angeles, CA
*Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
2022 American Transplant Congress
Top Molecules Associated with CLAD in Lung Transplants Are Shared Between Mucosal Biopsies, Transbronchial Biopsies, and Kidney Transplant Biopsies at Risk of Progression
M. Mackova¹, K. Halloran², P. F. Halloran¹, .. and the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) is a physiologic state with grave consequences for progression to failure but cannot be diagnosed by biopsy histology. We…
2022 American Transplant Congress
Association Between Maintenance Immunosuppressive Regimens And Covid-19 Mortality In Kidney Transplant Recipients
A. O. Gérard¹, S. Barbosa², D. Anglicheau³, L. Couzi⁴, M. Hazzan⁵, O. Thaunat⁶, G. Blancho⁷, S. Caillard⁸, A. Sicard¹
¹Nephrology, Nice University Hospital, Nice, France, ²Institute of Molecular and Cellular Pharmacology, CNRS, Valbonne, France, ³Nephrology, Necker University Hospital, APHP, Paris, France, ⁴Nephrology, Bordeaux Pellegrin University Hospital, Bordeaux, France, ⁵Nephrology, Lille University Hospital, Lille, France, ⁶Nephrology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France, ⁷Nephrology, Nantes University Hospital, Nantes, France, ⁸Nephrology, Strasbourg University Hospital, Strasbourg, France
*Purpose: Kidney transplant recipients (KTR) are at increased risk of mortality from COVID-19. We conducted a cohort study among KTR from the French Solid Organ…
2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
2022 American Transplant Congress
A Randomized, Controlled, Double-blind Trial Of Inulin To Boost Response To A Third Covid-19 Vaccine Dose In Kidney Transplant Recipients.
J. Singer¹, M. Tunbridge², T. Salehi³, G. Perkins⁴, B. Grubnor-Bauk⁵, B. Sim³, T. Ying⁶, P. T. Coates³, S. J. Chadban¹
¹Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia, ²Renal Medicine, Royal Adelaide Hospital, Adelaide, Australia, ³Royal Adelaide Hospital, Adelaide, Australia, ⁴School of Biological Sciences, University of Adelaide, Adelaide, Australia, ⁵Adelaide University, Adelaide, Australia, ⁶Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) commonly exhibit inadequate responses to 2-dose COVID-19 vaccination schedules and remain at increased risk of severe COVID-19. Gut dysbiosis is…
2022 American Transplant Congress
Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals
L. Donadeu¹, S. Gomez¹, A. Fava'², E. Crespo¹, F. Moreso³, M. Lopez³, L. Lladó⁴, J. González⁴, I. Campos³, M. Muñoz³, J. Quintero³, J. Esperalba³, O. Bestard³
¹Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ²Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, ⁴Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain
*Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…
2022 American Transplant Congress
Trajectory Analysis Of Single Cell RNAseq Data Suggest Intrarenal Induction Of Tregs In Spontaneously Accepted Kidney Allografts
M. Guinn¹, E. S. Szuter¹, T. Yokose¹, J. Ge², B. Kwon¹, I. Rosales³, P. S. Russell¹, A. Cuenca², J. Madsen¹, R. Colvin³, A. Alessandrini¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted independent of the recipient’s thymus, spleen, and lymph nodes.…
2022 American Transplant Congress
Place Based Risk for Early Rejection in Lung Transplant
W. M. Tsuang¹, X. Wang², J. Curtis³
¹Respiratory Institute, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
*Purpose: Within 5 years after lung transplant (LT), half of recipients have lost 20% or more of lung function. Despite a consistent link between social…