Abstracts Archive - Page 101 of 1683 - ATC Abstracts

2022 American Transplant Congress
Longitudinal Characterization of Memory B Cells During Antibody Mediated Rejection Treated with Plasmapheresis, Bortezomib, and Belatacept in Heart Transplant Recipients
F. Alkhunaizi¹, M. Ellison², V. Berrich¹, M. Siegelin¹, M. Szabolcs¹, G. F. Sayer¹, N. Uriel¹, S. Restaino¹, A. Chong³, A. Zeevi², M. Habal¹
¹Columbia University Medical Center, New York, NY, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³University of Chicago, Chicago, IL
*Purpose: Donor specific antibodies (DSA) and antibody mediated rejection (AMR) continue to limit allograft longevity after heart transplant. Effective treatments are limited and often complicated…
2022 American Transplant Congress
Preemptive  Therapy for Cytomegalovirus (CMV) Disease Prevention in High-Risk CMV Donor Seropositive Recipient Seronegative (D+/R-) Liver Transplant Recipients in a Real-World Setting 
K. M. Doss¹, C. Kling¹, M. R. Heldman¹, N. Singh², M. Wagener³, C. E. Fisher¹, A. Limaye¹
¹University of Washington, Seattle, WA, ²University of Pittsburgh, PIttsburgh, PA, ³University of Pittsburgh, Pittsburgh, PA
*Purpose:  Preemptive therapy  (PET)  has  demonstrated superiority to antiviral prophylaxis  for  prevention of  cytomegalovirus (CMV)  disease  in  CMV  donor seropositive/recipient seronegative (D+R-)  liver transplant recipients …
2022 American Transplant Congress
Development of a Portable Device to Quantify Hepatic Steatosis in Donated Livers Using an AI Algorithm
S. Klinkachorn¹, C. J. Tsoi-A-Sue², R. R. Narayan², M. L. Melcher²
¹Computer Science, Stanford, Stanford, CA, ²Surgery, Stanford, Stanford, CA
*Purpose: An accurate estimation of liver fat content is necessary to predict how a donor liver will function after transplantation. This can be challenging at…
2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Y. Park¹, D. Thadasina¹, K. Isidan¹, K. J. Lopez¹, A. Cross-Najafi¹, P. Li¹, H. Francis², G. Alpini², W. Zhang¹, B. Ekser¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN, ²Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
2022 American Transplant Congress
A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation
S. Hosgood¹, C. Callaghan², C. Wilson³, G. Oniscu⁴, B. Phillips⁵, L. Bates³, L. Smith⁶, M. L. Nicholson⁷
¹Surgery, University of Cambridge, Cambridge, United Kingdom, ²Transplant, Guys & St Thomas's, London, United Kingdom, ³Transplant, Freeman Hospital, Newcastle, United Kingdom, ⁴Edinburgh Royal Infirmary, Edinburgh, United Kingdom, ⁵Transplant, Guy's & St Thomas's, London, United Kingdom, ⁶NHSBT, NHSBT, Bristol, United Kingdom, ⁷University of Cambridge, Cambridge, United Kingdom
*Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…
2022 American Transplant Congress
Low T Cell Responsiveness in the Early Phase Of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
M. Cremoni¹, S. Cuozzo¹, E. Martinuzzi², S. Barbosa², N. Ben Hassen¹, F. Massa³, E. Demonchy⁴, M. Durand⁵, O. Thaunat⁶, V. Esnault¹, M. Lequintrec⁷, S. Caillard⁸, N. Glaichenhaus², A. Sicard¹
¹Service de Néphrologie, Dialyse, Transplantation rénale, Centre Hospitalier Universitaire de Nice, Nice, France, ²CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France, ³Université Côte d'Azur, Laboratoire de Physio-Médecine Moléculaire, Nice, France, ⁴Service d'Infectiologie, Centre Hospitalier Universitaire de Nice, Nice, France, ⁵Service d'Urologie, Centre Hospitalier Universitaire de Nice, Nice, France, ⁶Service de Transplantation rénale, Néphrologie et Immunologie clinique, Hôpital Edouard Herriot, Hospices civils de Lyon, Lyon, France, ⁷Service de Néphrologie, Dialyse, Transplantation rénale, Centre Hospitalier Universitaire Lapeyronie, Montpellier, France, ⁸Service de Néphrologie et Transplantation, Centre Hospitalier Universitaire de Strasbourg, Strasbourg, France
*Purpose: Kidney transplant (KT) recipients are more prone to developing life-threatening forms of COVID-19 than the general population. Little is known about the immunological mechanisms…
2022 American Transplant Congress
Trajectory Analysis Of Single Cell RNAseq Data Suggest Intrarenal Induction Of Tregs In Spontaneously Accepted Kidney Allografts
M. Guinn¹, E. S. Szuter¹, T. Yokose¹, J. Ge², B. Kwon¹, I. Rosales³, P. S. Russell¹, A. Cuenca², J. Madsen¹, R. Colvin³, A. Alessandrini¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted independent of the recipient’s thymus, spleen, and lymph nodes.…
2022 American Transplant Congress
Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients
S. Shaikh¹, I. Hasan¹, N. Kaur²
¹Keck Medicine of USC, Los Angeles, CA, ²Keck School of Medicine, Los Angeles, CA
*Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
2022 American Transplant Congress
COVID-19 Vaccination Induces a Poor Interleukin-21 Memory T-cell Response in Kidney Transplant Recipients
S. R. Malahe¹, Y. den Hartog¹, R. de Kuiper¹, D. Reijerkerk¹, D. Geers², C. H. GeurtsvanKessel², M. M. Kho¹, R. D. de Vries², M. E. Reinders¹, C. C. Baan¹
¹Internal Medicine, Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Viroscience, Erasmus MC, Rotterdam, Netherlands
*Purpose: COVID-19-related morbidity and mortality is high among kidney patients. Several studies recently suggested low humoral and cellular immune responses after two doses of mRNA-1273…
2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…