2022 American Transplant Congress
A Novel Prospective Validation Trial Of Multiple Blood-based RNA Signature Assays Pre And Post Kidney Transplant To Predict Rejection
*Purpose: The accuracy and utility of clinically defined and analytically validated predictive biomarkers in kidney transplantation is limited. We leveraged prior feasibility blood-RNA studies to…2022 American Transplant Congress
Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients
*Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…2022 American Transplant Congress
Early vs. Late Heparin Administration After Declaration of Death in DCD Donors Does Not Impact Short Term Outcomes in Kidney Transplantation
Organ Recovery, LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK
*Purpose: Kidneys from Donation after Cardiac Death (DCD) donors are well-known to have satisfactory outcomes post-transplant. In DCD donors, heparin is typically given immediately prior…2022 American Transplant Congress
A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients
*Purpose: To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.*Methods: This is a…2022 American Transplant Congress
A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation
*Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…2022 American Transplant Congress
A Randomized, Controlled, Double-blind Trial Of Inulin To Boost Response To A Third Covid-19 Vaccine Dose In Kidney Transplant Recipients.
*Purpose: Kidney transplant recipients (KTR) commonly exhibit inadequate responses to 2-dose COVID-19 vaccination schedules and remain at increased risk of severe COVID-19. Gut dysbiosis is…2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Immune Cell Profile in Kidney Allograft Fibrosis
*Purpose: A major obstacle after kidney transplantation (KT) is chronic allograft dysfunction characterized by interstitial fibrosis and tubular atrophy (IFTA). Despite extensive research, the cellular…2022 American Transplant Congress
SARS-CoV-2 Infection is Associated with Greater Neutralizing Antibody Response Compared to Three Doses of Mrna-1273 Vaccine in Solid Organ Transplant Recipients
University Health Network, Toronto, ON, Canada
*Purpose: Prior studies suggest that two doses of mRNA vaccine in SOTR may result in lower antibody and T-cell responses relative to levels seen following…2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…2022 American Transplant Congress
Evaluation of Donor Exclusion Criteria in Living Donor Liver Transplantation: A Single-Center Experience
Hepatobiliary Surgery and Liver Transplantation, Lahey Hospital and Medical Center, Burlington, MA
*Purpose: Liver donation is fundamental in increasing the pool of available grafts. Careful evaluation of each donor ensures the best outcomes for the recipient and…
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