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Outcomes in Pediatric Intestinal Retransplantation

E. J. Lee1, G. Mazariegos1, K. Soltys1, G. Bond1, A. Ganoza1, J. Rudolph2, S. Horslen2, R. Sindhi1, A. Khanna1

1Transplant Surgery, UPMC, Pittsburgh, PA, 2Division of Gastroenterology, Hepatology and Nutrition,, UPMC, Pittsburgh, PA

Meeting: 2022 American Transplant Congress

Abstract number: 347

Keywords: Pediatric, Retransplantation, Surgery, Survival

Topic: Clinical Science » Small Bowel » 66 - Intestinal Transplantation and Rehabilitation

Session Information

Session Name: Intestinal Transplantation and Rehabilitation

Session Type: Rapid Fire Oral Abstract

Date: Monday, June 6, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 6:20pm-6:30pm

Location: Hynes Room 206

*Purpose: Historically, intestinal retransplantation (Re-ITx) has been associated with high morbidity and mortality.

*Methods: Retrospective chart review of patients who underwent Re-ITx at our institution between 1990-2021 to assess improvements in survival outcome over time and by graft type.

*Results: Two hundred eighty-four children received primary intestinal grafts. 32 patients were listed for retransplantation. One patient died while waiting, 4 are awaiting retransplant and 27 children (9.5%) were retransplanted. 24 patients received a second transplant and 3 a third allograft. Patient demographics are shown in Table 1. Overall 5-and 10-year patient and graft survival were 76.5% and 51.7% and 75.1% and 51.0%, respectively, with mean follow-up of 89 months. (Figure 1A&B) 75% of patients attained full nutritional autonomy. Median graft survival for liver-contained (liver/intestine or MV) graft recipients was 183 months compared to 59.7 months for isolated intestinal retransplants. (Figure1C)

*Conclusions: Modern immunosuppression protocols, technical advances, and multidisciplinary management of children with intestinal failure, have led to favorableoutcomes and survival in patients with Re-ITx and recipients of liver-containing allografts.

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To cite this abstract in AMA style:

Lee EJ, Mazariegos G, Soltys K, Bond G, Ganoza A, Rudolph J, Horslen S, Sindhi R, Khanna A. Outcomes in Pediatric Intestinal Retransplantation [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-in-pediatric-intestinal-retransplantation/. Accessed May 8, 2025.

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