*Purpose: Mixed hepatocellular-cholangiocarcinoma (HCC-CC) is a biphenotypic liver cancer thought to have unfavorable tumor biology and a poor prognosis. Surgical outcomes of HCC-CC remain unclear. We aimed to evaluate the clinical and characteristics and surgical outcomes of HCC-CC.

*Methods: Case series of patients undergoing resection for HCC-CC (n=47), hepatocellular carcinoma (HCC) (n=468), and intrahepatic cholangiocarcinoma (ICC) (N=108) at a tertiary center between 2001 and 2015. Cases of HCC-CC were matched to cases of HCC and ICC on important clinical factors including tumor characteristics (size, vascular invasion, differentiation), and underlying cirrhosis.

*Results: Patients with HCC-CC had rates of viral hepatitis comparable to patients with HCC (78.5% vs. 80%) and 42.5% had underlying cirrhosis. When matched on tumor size (Figure 1A), HCC-CC was more poorly differentiated than HCC (68.3% vs. 27.3%, respectively; P<0.001) and ICC (68.3% vs. 34.8%, respectively, P=0.005) but had similar postresection survival (5-year survival: HCC-CC 49.7%, HCC 54.8%, ICC 68.7%, P=0.606) and recurrence (3-year recurrence: HCC-CC 57.9%, HCC 61.5%, and ICC 56%, P=0.549). Outcomes were similar between HCC-CC and HCC when matched on underlying cirrhosis and tumor size (Figure 1B). Cancer type was not predictive of survival or tumor recurrence.

*Conclusions: Survival after resection of HCC-CC is similar to HCC when matched for tumor size, despite HCC-CC tumors being more poorly differentiated. Exclusion of HCC-CC from management strategies recommended for HCC, including consideration for liver transplantation, may not be warranted.

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