ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Mycophenolate Mofetil and the Incidence of Skin Cancer in Kidney Transplant Recipients

S. J. Yusuf1, H. Bheemreddy1, A. Imtiaz2, N. Krishnan3

1Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom, 2Dermatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 3Renal Unit, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

Meeting: 2020 American Transplant Congress

Abstract number: A-225

Keywords: Azathioprine, Immunosuppression, Kidney transplantation, Post-transplant malignancy

Session Information

Session Name: Poster Session A: PTLD/Malignancies: All Topics

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Over the years there has been a shift in the use of anti-metabolites agents from azathioprine to mycophenolate mofetil (MMF) based immunosuppression., due to its better efficacy and less implication in the development of skin cancer compared to azathioprine. However, MMF is still potentially carcinogenic.

*Methods: Secondary data of 941 Kidney Transplant Recipients (KTRs) who received kidney transplantation, from 1st January1998 to 31st December 2018 was obtained. The incidence of skin cancer was determined in 429 KTRs immunosuppressed with MMF. Chi-square test of independence was used to determine the association between use of MMF based immunosuppression and the development of skin cancer, and also to determine the risk factors associated with types of skin cancers developed.

*Results: MMF was associated more with the development of Basal Cell Carcinoma (BCC) in both males and females 5(41.7%) Vs 5(50%) than Squamous Cell Carcinoma (SCC) 3(25%) Vs 2 (20%). Females had a higher incidence of skin cancer than males (10 (5.8%) Vs 12 (4.7%)) although this was not statistically significant (P=0.582). The BCC subtypes identified in females were nodular superficial and infiltrative BCCs, while males had mainly nodular BCCs. The SCC subtypes in females were moderately differentiated and well differentiated SCCs, while males had mainly moderately differentiated SCC.only one male (8.3%) developed post-transplant lymphoproliferative disorder (PTLD). Being Caucasian and ≥ 50 years of age at transplantation were significantly associated with development of skin cancer (PS=0.022 and P=0.005 respectively). Interestingly, recipients of Human Leucocyte Antigen incompatible transplants (HLAi) were not associated with development of skin cancer.

*Conclusions: We concluded that The BCC and SCC histological subtypes associated with use of MMF were not the aggressive forms and can be easily treated by surgical excision. KTRs on MMF based immunosuppression will benefit from regular skin assessments.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Yusuf SJ, Bheemreddy H, Imtiaz A, Krishnan N. Mycophenolate Mofetil and the Incidence of Skin Cancer in Kidney Transplant Recipients [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/mycophenolate-mofetil-and-the-incidence-of-skin-cancer-in-kidney-transplant-recipients/. Accessed May 11, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences