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Multi- National Survey among Nephrologists & Transplant Surgeons About the Suitability and Acceptance of the Marginal Live Kidney Donors with Sickle Cell Trait

Z. Arabi1, A. Mateen1, A. Altheaby1, M. Bukhari2, A. Hamad3, S. Kaysi4, E. Elhassan1

1KAMC, Riyadh, Saudi Arabia, 2Taif University, Taif, Saudi Arabia, 3The Regional Medical Center, Orangeburg, SC, 4CHU Clermont-Ferrand, Saint Pryv/ Saint Mesmin, France

Meeting: 2020 American Transplant Congress

Abstract number: B-081

Keywords: Donors, marginal, Kidney transplantation, Risk factors, Safety

Session Information

Session Name: Poster Session B: Kidney Living Donor: Selection

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: Due to organ shortage, many transplant centers may consider “marginal” kidney donors as those with sickle cell trait ( SCT) for donation. Acceptance of kidney donors with SCT is in the grey zone, where there are no clear guidelines or consensus toward them. To form a consensus, we conducted a short survey about the suitability and acceptance of living kidney donors with SCT.

*Methods: This is a cross-sectional survey of nephrologists and transplant surgeons about Suitability and Acceptance of The Marginal Live Kidney Donors. The survey was sent to nephrologists in different countries and it was also distributed through AST& ERA-EDTA.

*Results: Of a total of (n=122) respondents from 22 countries: 80.17% (N= 96) were nephrologists and 19.83% (N=23) were transplant surgeons. N= 88 of the respondents (72%) have more than 6 years in practice and they are heavily involved in pre- transplant evaluations of donors and recipients (68.5% of respondents perform donors’ evaluation on weekly or monthly basis and 60 % perform recipient evaluation on weekly basis). The majority (45%) of the respondents were from USA. The completion rate of the survey was 99%. The presence of sickle cell trait was not considered as a contraindication to donor nephrectomy by the majority of respondents (57.38%). Of those ( N= 34) 27.87 % of respondents consider them fit for donor nephrectomy after explanation of the risks involved while ( N= 36 ) 29.51 consider them for donor nephrectomy only if( N= 52) there is no other suitable donor available. Out of the total respondents ( N= 52) 42.62% considered the presence of sickle cell trait a contraindication to donor nephrectomy.

*Conclusions: With lack of consensus and guidelines we found that a significant pool of the transplant physicians and surgeons will consider donors with sickle cell trait for kidney donation especially if there is no other acceptable donor.

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To cite this abstract in AMA style:

Arabi Z, Mateen A, Altheaby A, Bukhari M, Hamad A, Kaysi S, Elhassan E. Multi- National Survey among Nephrologists & Transplant Surgeons About the Suitability and Acceptance of the Marginal Live Kidney Donors with Sickle Cell Trait [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/multi-national-survey-among-nephrologists-transplant-surgeons-about-the-suitability-and-acceptance-of-the-marginal-live-kidney-donors-with-sickle-cell-trait/. Accessed May 11, 2025.

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