Session Name: Kidney: Pediatrics
Session Date & Time: None. Available on demand.
*Purpose: Although pregnancy and delivery after kidney transplantation have been reported in many studies , it is still little known about growth and development of neonates born to kidney-transplanted women.
*Methods: We retrospectively included patients who became pregnant and gave birth after transplantation from October 2011 to November 2020, and matched post-transplant pregnant women with contemporaneous non-transplant pregnant women at 1:3 ratio by childbearing age, pregnant times, BMI and the mode of delivery in the same period.
*Results: In this study, a total of 24 recipients received kidney transplantation at the average age of 25.5±3.3Y/O. from September 2005 to December 2017 and became pregnant and gave birth at the average age of 29.9±2.5Y/O. from October 2011 to November 2020. All mothers were natural fertilization with single fetus in both two groups. In spite of higher incidence of preeclampsia(TX vs non-TX: 20.8% vs 4.2%, relative risk/RR: 4.95) in kidney-transplanted group, the incidence of gestational diabetes mellitus, intrahepatic cholestasis of pregnancy (12.5% vs 11.1%, RR=1.13; 8.3% vs 6.9%, RR=1.20, respectively) were similar. Although, compared with non-transplanted group, the rates of low birth weight and premature birth (29.2% vs 0 and 75% vs 0, both p values<0.05, respectively) were much higher in kidney-transplanted group, there is no significant difference in weight and height at 1st, 3rd, 6th, 9th, 12th, 18th month after birth (weight(kg): 4.07 vs 3.99, 6.62 vs 5.97, 8.18 vs 7.51, 8.83 vs 8.25, 10.04 vs 9.00, 11 vs 10.12, respectively; length(cm): 52.94 vs 52.7, 60.26 vs 59.7, 66.38 vs 66, 70.6 vs 70.1, 75.48 vs 73.8, 78.85 vs 79.6, respectively, all p values<0.05) compared with 2009 Reference Standard for Growth and Development of Children under 7 years old in China publicated by Chinese MINISTRY OF HEALTH, even better numerically, which both lower numerically than that of WHO Standard though.
*Conclusions: Although the rates of low birth weight and premature birth were far more than non-transplanted pregnancies, which was the same as the previous studies, the weight and length development of the neonates seems unaffected, which still needs more large- sample, long-term and random studies to confirm.
To cite this abstract in AMA style:Feng X, Song T, Zhong Q, Zeng J, Wang X, Fan Y, Huang Z, Lin T. Maternal Perinatal Condition and Neonatal Growth and Development After Renal Transplantation [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/maternal-perinatal-condition-and-neonatal-growth-and-development-after-renal-transplantation/. Accessed July 30, 2021.
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