ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Management and Outcomes of Coronavirus Disease 2019 in Solid Organ Transplant Recipients

A. Scott, Z. Truman, M. Manson

Baylor St. Luke's Medical Center, Houston, TX

Meeting: 2022 American Transplant Congress

Abstract number: 1659

Keywords: COVID-19, Immunosuppression, Infection

Topic: Clinical Science » Pharmacy » 30 - Non-Organ Specific: Clinical Pharmacy/Transplant Pharmacotherapy

Session Information

Session Name: Pharmacy II

Session Type: Poster Abstract

Date: Tuesday, June 7, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: The purpose of this study was to assess treatment of coronavirus disease 2019 (COVID-19) and immunosuppression modification in solid organ transplant (SOT) recipients, and identify risk factors that contribute to mortality among SOT recipients with COVID-19.

*Methods: The primary endpoint was 90-day mortality. Secondary endpoints include COVID-19 treatment regimen, laboratory abnormalities, maintenance immunosuppression modification, concomitant infections, complications such as renal replacement therapy (RRT) and more. This retrospective chart review included all SOT recipients who presented to our institution with a positive COVID-19 test over an 18-month period. Dual organ transplant recipients were excluded.

*Results: A total of 112 patients met inclusion criteria. The average age was 56 ± 13 years and 58% of patients were male. The majority of patients identified as Latino (39%), followed by African-American (29%) and Caucasian (28%). Forty-nine percent required treatment in the intensive care unit. Inflammatory markers were elevated in the majority of patients. Most immunosuppression modification strategies held antimetabolites and prednisone if receiving treatment with glucocorticoids. The primary endpoint of 90-day mortality was observed in 24% (27/112) of patients. Mortality rates by organ type can be found in Table 1. Common comorbidities in these patients are depicted in Figure 1. There was no significant difference in mortality between patients receiving remdesivir 12/27 vs. 20/85 (p=0.05). A 50% (4/8) mortality rate was observed among patients who received rabbit antithymocyte globulin within 6 months of COVID-19 infection (p=0.09). Concomitant respiratory infections showed a statistically significant difference in mortality 12/27 vs. 9/85 (p<0.05). All 6 patients that required extracorporeal membrane oxygenation expired. Fifty-two percent (14/27) of patients in the mortality group required RRT vs. 7% (6/85) of those that survived (p<0.05). While most cases were prior to the advent of COVID-19 vaccines, all 9 patients that received at least one dose of any COVID-19 vaccine prior to infection survived at 90 days.

*Conclusions: Concomitant respiratory infections and RRT were significant predictors of mortality among SOT recipients with COVID-19. Administration of rabbit antithymocyte globulin within 6 months of COVID-19 infection and treatment with remdesivir should be investigated in future studies as they may demonstrate significant associations in a larger sample size.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Scott A, Truman Z, Manson M. Management and Outcomes of Coronavirus Disease 2019 in Solid Organ Transplant Recipients [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/management-and-outcomes-of-coronavirus-disease-2019-in-solid-organ-transplant-recipients/. Accessed May 28, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences