Introduction:3-methyl histidine (3MH) is a non-proteinogenic amino acid and an index of muscle breakdown. Subclinical protein malnutrition is an independent association with arterial stiffness. The present study evaluated the relationship between fasting serum 3MH level and peripheral arterial stiffness (PAS) in renal transplant recipients.

Materials and Methods: Fasting blood samples were collected from 67 renal transplant recipients. In this study, we applied an automatic pulse wave analyzer (VaSera VS-1000) to measure the brachial-ankle pulse wave velocity (baPWV). A baPWV value greater than 14.0 m/s on either side was considered high PAS.Serum 3MH level was performed with high-performance liquid chromatography and mass spectrometry.

Results: Thirty-seven renal transplant recipients had high PAS, and they included a higher percentage of patients with diabetes,hypertension, older age, and a higher renal transplant duration,systolic blood pressure, diastolic blood pressure, serum triglyceride, while lower serum 3MH levels compared with renal transplant recipients without PAS.After adjusting for factors significantly associated with PASin these patients by multivariate logistic regression analysis,3MA(Odds ratio (OR): 0.841, 95% confidence interval (CI): 0.754–0.938, P= 0.002) was independently associated with PAS in renal transplant recipients

.The area under the receiver-operating characteristic (ROC) curve indicates the diagnostic power of 3MH at predicting PAS of renal transplant recipients was 0.813 (95% CI: 0.699-0.898, P < 0.001) .

Conclusion:The serum fasting 3MH level is negatively associated with PAS in renal transplant patients.

CITATION INFORMATION: Hsu B-.G., Lai Y-.H., Hou J., Liu C-.H., Lee M-.C. Low Serum 3-Methyl Histidine Level is Associated with Peripheral Arterial Stiffness in Renal Transplant Recipients Am J Transplant. 2017;17 (suppl 3).

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