ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Long-Term Outcomes of Liver Transplantation (LT) Using Grafts from Donors with Active and Chronic Hepatitis B Virus (HBV) Infection; Multi-Center Cohort Study

S. Suh1, S. Gang2, Y. Choi2, S. Hong2, N. Yi2, K. Lee2, K. Suh2

1Chung-Ang University, Seoul, Korea, Republic of, 2Seoul National University, Seoul, Korea, Republic of

Meeting: 2022 American Transplant Congress

Abstract number: 885

Keywords: Donors, marginal, Hepatitis B, Outcome

Topic: Clinical Science » Liver » 59 - Liver: Expanding the Donor Pool* (Liver: MELD Allocation / Donor Issues)

Session Information

Session Name: Liver: Expanding the Donor Pool* (Liver: MELD Allocation / Donor Issues)

Session Type: Poster Abstract

Date: Saturday, June 4, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 5:30pm-7:00pm

Location: Hynes Halls C & D

*Purpose: Liver grafts from donors with hepatitis B infection contributed to expand the donor pool under the Hepatitis B immunoglobulin (HBIG) and antiviral agents (NA: Nucleos(t)ide analogues) in the hepatitis B virus (HBV) endemic area. We report the long-term outcome of liver transplantation (LT) using grafts from donors with active and chronic hepatitis B virus infection

*Methods: Among 2260 LTs performed in Seoul National University (SNU) Hospital, SNU Bundang Hospital (SNUBH), and Seoul Metropolitan Government-SNU Boramae Hospital between January 2000 and April 2019, twenty-six (1.2%) grafts from donors with HBsAg (+), HBeAb (+) or HBV DNA (+) were referred as active and chronic HBV hepatitis grafts and reviewed retrospectively.

*Results: Sixteen deceased donor LT were performed with active HBsAg (+) grafts. Ten living donor LT were performed with inactive HBV infected grafts; eight patients in inactive hepatitis status; HBsAg (-), HBcAb (+) & HBV DNA (+), and two patients in chronic HBV hepatitis with seroconversion; HBsAg (-), HBsAb (+) and HBeAg (+). Recipients’ age was 59.0±10.3 years old and MELD score was 19.9±8.4. Average follow-up period was 82.6±60.1 months. NA and HBIG were administered during perioperative period depending on donor and recipient’s serology. Deaths (n=8) were occurred 2.0-47.3 months after transplantation. All deaths were reported in DDLT. When compared with the patients who underwent LT using non-hepatitis virus-infected grafts, there was no significant difference in patient survival (30.8% vs. 18.6%, p=0.247). Most common causes of death were infection (n=4) and HCC recurrence (n=3). All recurred HCC patients were died of cancer. HBV reactivation was identified in 1 patient but resolved spontaneously without additional management. All 10 LDLT recipients survived and were in good condition during follow-up. Survivors were in inactive or resolved status for HBV infection under the HBIG and NA. No graft failure was observed. Fourteen patients followed-up more than 5 years were stable and no increase in HCC recurrence rate was observed 5 years after transplantation.

*Conclusions: Considering their long-term outcome, liver grafts with active and chronic HBV infection can be safely used in HBV endemic area.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Suh S, Gang S, Choi Y, Hong S, Yi N, Lee K, Suh K. Long-Term Outcomes of Liver Transplantation (LT) Using Grafts from Donors with Active and Chronic Hepatitis B Virus (HBV) Infection; Multi-Center Cohort Study [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-outcomes-of-liver-transplantation-lt-using-grafts-from-donors-with-active-and-chronic-hepatitis-b-virus-hbv-infection-multi-center-cohort-study/. Accessed June 5, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences