*Purpose: To identify clinical outcomes and complications of living donor nephrectomies in the US from 2008 – 2015.

*Methods: A retrospective analysis of 2008-2015 discharge data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) was performed using the International Classification of Diseases, Ninth Revision (ICD-9), codes. Clinical outcomes were analyzed for patient and provider characteristics. Complications were predicted using data mining tools and were defined as Bleeding, Wound, Respiratory, Urologic, Cardiac and Other. Table 1 shows the definition of postoperative complications grade level diagnosis by The Clavien-Dindo Classification. for predicting the complications level after living donor nephrectomy. Features correlation is measured, and selected predictors and their correlation plots are shown in Figure 1.

*Results: Figure 2 shows the map of factors leading to postoperative complications. Based on these maps, female donors with obesity and nonwhite ethnicity are more at risk of having post-surgery complications than other patients.

*Conclusions: A total of 9,837 live donor nephrectomies were identified with 0.4% mortality and a complication rate of 4.62%. Live kidney donation has low mortality and complication rates. Donation by those with advanced age or obesity is associated with higher risks. Informed consent should include discussion of these risks.

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