Landscape of Non-Directed Live Donors

K. Kumar, X. Luo, A. Massie, T. Purnell, J. Tonascia, E. King, D. Segev.

Johns Hopkins, Baltimore, MD.

Meeting: 2015 American Transplant Congress

Abstract number: C160

Keywords: African-American, Donation, Kidney transplantation, Waiting lists

Session Information

Session Name: Poster Session C: Living Donor Issues 2

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Background: The use of kidneys from Non-directed live donors (NDLD) among transplant centers in the US is unknown and the recipient selection remains varied. We explored trends in NDLD demographics and their recipients compared to directed live donors (DLD) and wait list candidates (WL).

Methods: SRTR data was used to explore demographics of NDLD and DLD from 2000-2013.

Results: The number of NDLDs has increased per year from 20 in 2000 to 154 in 2013. Compared with DLDs, a higher proportion of NDLDs were Caucasian (92.9% vs. 69.5% p<0.001), male (45.3% vs. 40.1% p<0.001), and educated with a college degree (67.6% vs. 49% p<0.001).

Table 1. Characteristics of all NDLD compared to DLD over time in the US from 2000-2013. * is noted for variables that are statistically significant.
	NDLD 2000-2013 n=1,237	DLD 2000-2013 n=84,474
Age Median (IQR)*	46(35-54)	41(32-49)
Male (%)*	45.2	40.2
ABO type (%)*
A	39	26.2
AB	4.5	0.9
B	12.1	7.8
O	44.4	65.1
Race (%)*
Caucasian	92.8	69.5
AA	2.3	12.7
Other	4.9	17.8
Education*
No college	16	26.2
College and Above	67.6	49
Median (IQR) BMI*	25.2(22.7-28.1)	26.6(23.7-29.7)

Compared with WL, a higher proportion of NDLD recipients were Caucasian (p<0.001).

Table 2. Characteristics of NDLD Recipients compared to DLD Recipients and DDWL Candidates in the US from 2000-2013.
	Recipients of NDLD	Recipients of DLD	WL Candidates	p(NDLDvs.DLD)	p(NDLDvs.WL)
Median Age (IQR)	48(37-58)	47(34-57)	52(42-61)	0.002	<0.001
Male (%)	59.7	60.3	60.1	0.7	0.8
Race (%)				0.006	<0.001
Caucasian	64.2	67.3	47.3
AA	17.3	14.2	29.1
Other	18.5	18.5	23.6
Median BMI (IQR)	27(23.3-31.2)	26.2(22.7-30.5)	27(24-32)	<0.001	<0.001
Median years on dialysis (IQR)	2(0.5-3.9)	0.8(0-1.9)	0.9(0.1-2.4)	<0.001	<0.001
Previous kidney Txp (%)	12.1	10.5	13.6	0.06	0.1
ABO type (%)				<0.001	<0.001
A	40	38.2	33
AB	6.5	3.8	3.9
B	15.1	13	14.6
O	38.4	45	48.5
Medians years on the waitlist (IQR)	1.4(0.6-2.7)	0.5(0.3-1.1)	0.9(0.1-2.)	<0.001	<0.001
Median PRA (IQR)	2(0-21)	0(0-8)	0(0-5)	<0.001	<0.001

50% of all NDLD transplants were clustered among just 23 centers.

Conclusion:NDLD tend to be Caucasian, male, and have a higher education level. Recipients of NDLD kidneys have been on dialysis and waitlist for a longer time than DLD. NDLD has disproportionately benefited Caucasian patients.

To cite this abstract in AMA style:

Kumar K, Luo X, Massie A, Purnell T, Tonascia J, King E, Segev D. Landscape of Non-Directed Live Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/landscape-of-non-directed-live-donors/. Accessed May 11, 2025.

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