Incidence of Post Transplant BKV Infection Using Two Different Cut-Offs for BKV IgG Seropositivity
Medicine, University of Pittsburgh Medical Center, Pittsburgh
Surgery, Medical College of Wisconsin, Milwaukee
Meeting: 2013 American Transplant Congress
Abstract number: C1368
Background: The study evaluated relationship of pre transplant BKV specific donor/recipient serostatus to post-transplant BKV infection, using two different cut-offs to define seropositivity.
Methods: 240 adult de-novo kidney-only recipients were prospectively enrolled and followed for a minimum of 18 months. Baseline data on Donor and Recipient demographics, transplant variables, BKV humoral specific immune status and post-transplant variables were collected. Pre-transplant BKV serostatus was available for 192 adult donor-recipient pairs. Based on BKV specific IgG EIA cut off of ≥ 8 units and ≥ 4 units, subjects were divided into 4 groups: D+R+,D+R-,D-R+ and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12 and 24 months. The outcomes studied were development of any BKV infection, viremia and significant viremia (>10,000 copies/ml plasma).
Results: The details of 192 study subjects according to the respective donor-recipient status, for each respective cut-off are summarized in Table 1.
| BKV infection(Cut off ≥ 4 EIA) | D+R- (N= 44) | D+R+ (N=121) | D-R+ (N=21) | D-R- (N=13) |
| BK viruria alone | 6 (14%) | 20 (16%) | 3 (14%) | 1 (7.6%) |
| BK viremia | 19 (43%) | 38 (31%) | 5 (24%) | 3 (23%) |
| All Infection | 25 (57%) | 58 (48%) | 8 (38%) | 4 (31%) |
| BKV infection (Cut-off ≥ 8 EIA) | D+R- (N=41) | D+R+ (N=42) | D-R+ (N=41) | D-R- (N=68) |
| BK viruria alone | 5 (18%) | 8 (19%) | 5 (12%) | 9 (13%) |
| BK viremia | 20 (49%) | 14 (33%) | 12 (29%) | 16 (23%) |
| All Infection | 25 (61%) | 22 (52%) | 17 (41%) | 25 (36%) |
Higher incidence of BKV infection was seen in D+R- group irrespective of IgG threshold of ≥ 4 EIA units or ≥ 8 EIA units.
Conclusions: BKV serostatus can be used to risk stratify patients for all post-transplant BK infection and development of BK viremia.
To cite this abstract in AMA style:
Sood P, Cronin D, Johnson C, Hariharan S. Incidence of Post Transplant BKV Infection Using Two Different Cut-Offs for BKV IgG Seropositivity [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/incidence-of-post-transplant-bkv-infection-using-two-different-cut-offs-for-bkv-igg-seropositivity/. Accessed November 22, 2024.« Back to 2013 American Transplant Congress