Impact of Recipient Obesity on Kidney Transplantation Outcome: A Retrospective Cohort Study with a Matched Comparison
A. Buemi
Surgery, Cliniques Universitaires Saint Luc, Bruxelles, Belgium
Meeting: 2022 American Transplant Congress
Abstract number: 760
Keywords: Kidney transplantation, Obesity, Outcome
Topic: Clinical Science » Kidney » 35 - Kidney: Cardiovascular and Metabolic Complications
Session Information
Session Name: Kidney: Cardiovascular and Metabolic Complications
Session Type: Poster Abstract
Date: Saturday, June 4, 2022
Session Time: 5:30pm-7:00pm
Presentation Time: 5:30pm-7:00pm
Location: Hynes Halls C & D
*Purpose: The aim of this study was to evaluate the effect of recipient obesity on posttransplant complications and patient and graft survival.
*Methods: A single-institution, retrospective study was performed on obese renal transplant recipients (BMI > 30 kg/m2, n=102) from January 2010 to December 2018, matched with non-obese recipients (BMI < 30 kg/m2, n=204). For comparison, for every obese patient we selected two non-obese patients with a similar age, gender, and period of transplantation. The comparative analysis included patient and graft survival as primary outcomes and graft function and postoperative complications as a secondary outcome.
*Results: Recipient demographics were comparable in both groups except for diabetic nephropathy in obese patients (p=0,0006). Obesity was strongly related to a poorer patient survival (RR=2,83 CI 95% 1,14-7,04; p=0,020) but no difference in graft survival was observed (p=0.6). While early graft function was inferior in the obese population (RR=2,41; CI 95% 1,53-3,79; p=0,00016), during late follow-up, no statistically significant differences were observed between both groups (p=0,36). Obese recipients had a significantly higher risk of DGF (RR=1,93; CI 95% (1,19-3,1), p=0,0077), heart infarction (RR=7 CI 95% 1,68-29,26; p=0,0042), wound infections (RR=8; CI 95% 1,96-32,87; p=0,0015), diabetes aggravation (RR=3,13; CI 95% 1,29-7,6; p=0,011), and surgical revision for eventration (RR=8; CI 95% 1,22-52,82; p=0,026) when compared with non-obese recipients.
*Conclusions: Despite the inferior early kidney graft function in obese recipients, no difference was observed at the long-term follow-up. However, recipient obesity demonstrated a negative impact on patient survival and post-operative complications.
To cite this abstract in AMA style:
Buemi A. Impact of Recipient Obesity on Kidney Transplantation Outcome: A Retrospective Cohort Study with a Matched Comparison [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-recipient-obesity-on-kidney-transplantation-outcome-a-retrospective-cohort-study-with-a-matched-comparison-2/. Accessed November 21, 2024.« Back to 2022 American Transplant Congress