ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of Proton Pomp Inhibitors on Hypomagnesemia and Arterial Stiffness in Renal Transplant Recipients

S. Sezer,1 B. Gurlek Demirci,1 M. Erkmen Uyar,1 S. Uyanik,2 M. Haberal.3

1Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey
2Department of Intrenal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey
3Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.

Meeting: 2015 American Transplant Congress

Abstract number: A185

Keywords: Arteriosclerosis, Metabolic complications, Renal function

Session Information

Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic

Session Type: Poster Session

Date: Saturday, May 2, 2015

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Exhibit Hall E

Purpose: Hypomagnesemia predicts cardiovascular morbidity and mortality in the general population and accelerated loss of kidney function in renal transplant recipients (RTRs). Proton pomp inhibitors (PPIs) or H2 receptor blockers (H2RBs) are frequently used agents after RT. Recent studies highlighted the association between hypomagnesemia and PPIs in healthy population and patients ongoing hemodialysis. The aim of this study was to evaluate the effects of PPIs on serum magnesium levels and arterial stiffness in RTRs.

Materials and Methods: We performed a retrospective study of 354 maintenance RTRs (mean age: 38.6 ± 10.7 years) with stable allograft function who had received their transplant at least 36 months previously. All acute cellular and humoral rejections were excluded. According to using stomach-protecting agents (SPAs), patients were divided in to three groups: PPIs (Group 1, n: 164), H2RBs (Group 2, n: 96) and control group who don't receive SPAs (Group 3, n: 94). Clinical and laboratory parameters (complete blood count, creatinine, calcium, phosphorus, magnesium, vitamin B12, folic acid, lipid profile) were noted from recorded data. Estimated glomerular filtration rate (eGFR) was calculated by using the MDRD4 equation. Pulse wave velocity (PWv) was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system.

Results: Groups were similar in means of demographic characteristics and biochemical parameters. Mean serum magnesium levels were significantly lower in group 1, however similar in group 2 and 3 (1.5 ± 0.04 mg/dl, 1.7 ± 0.02 mg/dl and 1.7 ± 0.01 mgdl, respectively). PWv values were significantly higher in group 1, whereas similar in group 2 and 3 (7.3 ± 0.2 cm/sec, 6.3 ± 0.1cm/sec and 6.2 ± 0.1 cm/sec, retrospectively). In linear regression analysis; type of SPAs (p: 0.001), serum calcium (p: 0.031), magnesium (p: 0.07) and folic acid levels (p: 0.013) were detected as the predictors of PWv.

Conclusion: We concluded that PPIs inhibit magnesium absorbtion independent from calcium metabolism in RTRs. Moreover, PPIs leads to increased arterial stiffness and cardiovascular risk in RTRs. Thus physicians should be aware of the side effects of PPIs to scale down the cardiovascular morbidity and mortality.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Sezer S, Demirci BGurlek, Uyar MErkmen, Uyanik S, Haberal M. Impact of Proton Pomp Inhibitors on Hypomagnesemia and Arterial Stiffness in Renal Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-proton-pomp-inhibitors-on-hypomagnesemia-and-arterial-stiffness-in-renal-transplant-recipients/. Accessed May 31, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences