Impact of Long-Term Pretransplant Dialysis Was Not Noted on the Survival of Renal Grafts from DCD Donors
Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
Meeting: 2013 American Transplant Congress
Abstract number: C1281
Introduction:
Because of worldwide organ shortage, the average waiting period for a cadaveric renal graft is about 15 years in Japan. Therefore, recipients tend to be older and the dialysis period is also longer than other countries. In this study, we investigated the relationship between the dialysis period and outcomes of renal grafts donated after cardiac death (DCD).
Methods :
This study included 127 recipients who underwent kidney transplant between 1990 and 2012 at our institute. Median age of the recipients was 44 years (range, 15 – 63), and 64.6% were male. Median period of the dialyses before kidney transplants was 122 months (range, 12 – 401). Median follow-up time was 101 months (range, 8 – 264). These recipients were stratified: pretransplant dialysis periods shorter than 5 years (n=31) [G1], from 5 to 15 years (n=63) [G2] and longer than 15 years (n=33) [G3].
Results:
Median pretransplant dialysis period were 43 in G1, 119 in G2 and 210 months in G3. Median acute tubular necrosis period and primary nonfunction were not different among the three groups (9.0, 6.0 and 7.0 days, and 3.2, 1.6 and 6.1%). Median age was significantly older in the recipients with longer pretransplant dialysis period (38, 44 and 49 years old, p=0.0001). The rate of acute rejection was significantly lower in the recipients with longer pretransplant dialysis period (67.7, 46.0 and 19.3%, p=0.0003). Three-year, 5-year and 10-year patient survival rates (%) were not significantly different (G1 ; 96.7, 93.1 and 89.0, G2 ; 96.7, 93.0 and 87.8, G3 ; 93.1, 93.1 and 73.7). Three-year, 5-year and 10-year graft survival rates were also not significantly different (G1 ; 96.7, 86.7 and 66.7, G2 ; 96.7, 91.1 and 72.5, G3 ; 89.3, 89.3 and 53.2).
Conclusion :
This study showed that the pretransplant dialysis period was not significantly correlated with patient and graft survivals in DCD renal transplants.
To cite this abstract in AMA style:
Takenaka M, Kusaka M, Sasaki H, Kubota Y, Fukami N, Shiroki R, Kenmochi T, Hoshinaga K. Impact of Long-Term Pretransplant Dialysis Was Not Noted on the Survival of Renal Grafts from DCD Donors [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/impact-of-long-term-pretransplant-dialysis-was-not-noted-on-the-survival-of-renal-grafts-from-dcd-donors/. Accessed May 17, 2025.« Back to 2013 American Transplant Congress