ATC Abstracts

American Transplant Congress abstracts

Impact of Donor and Recipient Pretransplant EBV Antibody Status on PTLD Incidence in Adult Kidney Transplant Recipients

Surgery and Lab Medicine and Pathology, U Mn, Mpls, MN

Meeting: 2013 American Transplant Congress

Abstract number: D1716

We studied the impact of pretransplant (pretx) EBV antibody (ab) status on the incidence of PTLD in adult primary kidney tx recipients. Between 1/2002 and 12/2011, 1446 adults with known pretx EBV ab status underwent primary tx (609 DD; 837 LD). All recipients were followed through 9/2012.

Adult EBV-naive (ab negative pretx) recipients were significantly more like to develop PTLD (p<0.0001) (Table 1). New onset PTLD occurred throughout the years of follow-up in the EBV-naive recipients (Table 1). For EBV ab+ recipients, mean age (±SD) at transplant was 51± 13 yrs; for EBV-naive recipients, 45±15 yrs (p.=0.0005). For EBV ab+ recipients, mean age (±SD) at PTLD diagnosis was 57±12; for EBV naive recipients, 56±17 (NS). The risk of PTLD was similar for EBV- naive recipients who received a living or deceased donor kidney (Table 1).

Table 1: Actuarial PTLD-free Survival by EBV Status (Primary Tx)
Yrs Post Tx % PTLD Survival
  EBV- (n=87) EBV+ (n=1277)   DD, EBV- (n=32) DD, EBV+ (n=521) LD, EBV- (n=55) LD, EBV+ (n=756)
1 99.7% 99.8%   96.4% 99.3% 100% 100%
2 99.7% 99.7%   96.4% 99.3% 100% 99.9%
3 96.7% 99.7%   96.4% 99.1% 96.4% 99.9%
4 94.5% 99.4%   91.6% 99.1% 96.4% 99.6%
5 94.5% 99.4%   91.6% 99.1% 96.4% 99.6%
6 90.7% 99.4%   91.6% 99.1% 90.4% 99.6%
7 90.7% 99.4%   91.6% 99.1% 90.4% 99.6%
8 90.7% 99%   91.6% 99.1% 90.4% 99.1%
9 79% 99%   91.6% 99.1% 90.4% 99.1%

1083 recipients had complete information on donor (D) and recipient (R) EBV status. PTLD-free survival by D/R status is shown in Table 2 (D+/R+; D+R-; D-R+; D-R-). D+/R- transplants were associated with significantly ⇓ PTLD-free survival vs D+/R+ (p=0.008) and D-R- (p=0.01).

Table 2: Actuarial PTLD-free Survival by Donor and Recipient EBV Serology
Yrs Post Tx % PTLD-free Survival
  D+ R+ (n=944) D+ R- (n=66) D- R+ (n=67) D- R- (n=6)
1 99.9% 100% 98.4% 100%
2 99.8% 100% 98.4%

To cite this abstract in AMA style:

Chandolias N, Gillingham K, Balfour H, Matas A. Impact of Donor and Recipient Pretransplant EBV Antibody Status on PTLD Incidence in Adult Kidney Transplant Recipients [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/impact-of-donor-and-recipient-pretransplant-ebv-antibody-status-on-ptld-incidence-in-adult-kidney-transplant-recipients/. Accessed November 22, 2024.

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