Impact of Disease Duration on Islet Yield for Clinical Islet Autotransplants for Chronic Panreatitis
Islet Cell Laboratory, Baylor Research Institute, Dallas/Fort Worth, TX
Institute for Biomedical Studies, Baylor University, Waco, TX
Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX
Meeting: 2013 American Transplant Congress
Abstract number: D1577
Background: Total pancreatectomy followed by autologous islet transplantation (TP-AIT) is an advanced surgical option for refractory chronic pancreatitis (CP) patients. Islet yield is an important factor to predict post-transplant endocrine function; however, the relationship between disease duration and islet yield has not been clarified.
Methods: A total of 51 CP patients with TP-AIT were included. The patients were divided into four groups according to disease duration (DD) of 10 years and pancreatic calcification (PC) in clinical studies of X-ray, transabdominal/endoscopic ultrasonography or computed tomography. Islet isolation was performed with modified Ricordi method. Total islet yield, islet yield per pancreas weight and islet yield per patient body weight were evaluated.
Results: No significant differences were found in basic characteristics between DD>10yrs and ≤10yrs group for each PC classification (Table).
| Calcification: positive | Calcification: negative | |||||
| Variables | DD<10 yrs
(n=17) |
DD≥10 yrs
(n=4) |
p value | DD<10 yrs
(n=22) |
DD≥10 yrs
(n=8) |
p value |
| Age (years) | 47±2 | 43±5 | 0.51 | 38±2 | 37±5 | 0.82 |
| Sex; Female | 11 (65%) | 2 (50%) | 0.62 | 17 (77%) | 6 (75%) | 1.0 |
| Body mass index (kg/m2) | 23.7±1.1 | 21.2±0.8 | 0.30 | 27.6±1.1 | 27.4±1.7 | 0.94 |
| HbA1c (%) | 6.2±0.4 | 6.7±1.0 | 0.62 | 5.9±0.2 | 6.0±0.5 | 0.88 |
| Cold ischemia time (min) | 43±3 | 40±4 | 0.68 | 40±3 | 40±4 | 0.98 |
| Pancreas weight (g) | 86±7 | 68±11 | 0.26 | 85±5 | 88±12 | 0.84 |
DD≤10yrs group had significantly higher total islet yield and islet yield per patient body weight for both PC classification, and islet yield per pancreas weight for positive PC (Figure, *p<0.05 and §p<0.1).
Conclusions: Higher islet yield can be expected if CP patients have disease duration less than 10 years when classified by pancreatic calcification.
To cite this abstract in AMA style:
Takita M, Shahbazov R, Kanak M, Kunnathodi F, Lawrence M, Onaca N, Levy M, Naziruddin B. Impact of Disease Duration on Islet Yield for Clinical Islet Autotransplants for Chronic Panreatitis [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/impact-of-disease-duration-on-islet-yield-for-clinical-islet-autotransplants-for-chronic-panreatitis/. Accessed May 14, 2025.« Back to 2013 American Transplant Congress