*Purpose: Live donor liver and kidney donations are very effective procedures to increase the available organ pool and shorten waiting list for the patients listed for transplant. Living donor candidates are healthy individuals with no medical conditions who undergo a very comprehensive evaluation before the procedure. One of the most important criteria for live liver and kidney donors is to have normal coagulation profile, however despite a very complete medical examination sometimes the donors could experience some post donation complications such as deep vein thrombosis DVT or pulmonary embolism PE. Therefore, in this study we aimed to investigate the incidence rate of DVT and PE in both liver and kidney living donors after the donation procedure.

*Methods: Total number of 178, donors 42 liver and 136 kidneys underwent live donation procedures in UMass Memorial Medical Center between 2008-2018. The donor population was divided into two liver and kidney groups. The demography of the donors like age, sex, gender, weight and height were compared between the two groups. Regarding coagulation profile, V Leiden factor, Cardiolipin G, Cardiolipin M, Protein S, Protein C activity and eventually Lupus anticoagulant factor were checked during donor evaluation stage. The data was gathered on DVT and PE incidence during donor’s follow-up after donation procedure. The data is reported as median±interquartile range and the p values were calculated using Mann-Whitney and Chi-square statistical tests.

*Results: There was no significant difference between the liver and kidney donors respecting donor sex, race, height and weight (p≥0.05). Donor age was significantly lower in the liver donors (40±17) compared to the kidney donor (49±20) (p=0.013). Regarding coagulation factors pre-donation, no significant difference was found in V Leiden factor, Cardiolipin G, Cardiolipin M, Protein S, Protein C activity and eventually Lupus anticoagulant between the both groups (p≥0.05). occurrence of donor DVT was significantly higher among liver donors (approximately 12%) versus no DVT occurrence in kidney donors (p=0.001). There was also higher PE trend in the liver donors (4.8%) versus no PE in the kidney donors with a very close p value to statistical significance (p=0.055).

*Conclusions: This study indicates that live liver donors are at higher risk of developing DVT and PE complications post-donation procedure while there is no risk for the kidney patients. This data also highlights the need for a new post donation health screen protocol in the live liver donors with better prophylaxis management.

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