High Frequency of HLA-DQ De Novo Donor Specific Antibodies is Independent of the Number of Mismatches in Heart Transplant
1HLA and Immunogenetics Laboratory/ Comprehensive Transplant Center, Cedars-Sinai Health Systems, Los Angeles, CA
2Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA.
Meeting: 2018 American Transplant Congress
Abstract number: 172
Keywords: Alloantibodies, Heart transplant patients, HLA antigens, HLA matching
Session Information
Session Name: Concurrent Session: The Guest That NEVER Leaves: Immunologic Challenges in Heart Transplantation
Session Type: Concurrent Session
Date: Sunday, June 3, 2018
Session Time: 4:30pm-6:00pm
Presentation Time: 5:42pm-5:54pm
Location: Room 4C-3
Aim: Development of de novo donor specific antibodies (DSA) after heart transplant is associated with an increased risk of allograft failure. The aim of this study was to determine the frequency of HLA serological antigen mismatch by locus and its relation to the development of de novo DSA in heart transplant.
Methods: The study cohort included adult heart transplant recipients at our institution between 2011 and 2015 (n=548). HLA serological antigen mismatch between the recipient and donor at HLA-A, -B, -C, -DRB1, -DRB3/4/5 and -DQ was assessed. HLA antibodies were tested quarterly for the first year and yearly thereafter using single antigen bead based assay.
Results: More HLA antigen mismatch was present at the HLA-B locus as compared to the other loci (p< 0.05, Fig 1A). We identified 76 recipients that developed 95 de novo DSA. 69 (73%) of these de novo DSA were against HLA-DQ. In contrast, only 4 DSA were against HLA-A, 4 were against HLA-B, 3 were against HLA-C, 3 were against HLA-DRB1, and 12 were against DR51/52/53. The ratio of HLA-DQ de novo DSA to HLA-DQ mismatches was 10%, which was much higher than other HLA loci (Fig1B).
Conclusion: Our data demonstrate that the high frequency of HLA-DQ de novo DSA is not dependent on the number of mismatches. HLA-DQ mismatches have higher immunogenicity than the other HLA antigens. 
CITATION INFORMATION: Zhang X., Kransdorf E., Patel J., Kobashigawa J. High Frequency of HLA-DQ De Novo Donor Specific Antibodies is Independent of the Number of Mismatches in Heart Transplant Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Zhang X, Kransdorf E, Patel J, Kobashigawa J. High Frequency of HLA-DQ De Novo Donor Specific Antibodies is Independent of the Number of Mismatches in Heart Transplant [abstract]. https://atcmeetingabstracts.com/abstract/high-frequency-of-hla-dq-de-novo-donor-specific-antibodies-is-independent-of-the-number-of-mismatches-in-heart-transplant/. Accessed November 21, 2024.« Back to 2018 American Transplant Congress