ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

HCV+ Waitlist Candidates More Likely to Die Waiting for Kidney Transplant from HCV- Donor.

B. Shelton,1 D. Sawinski,2 S. Mehta,1 R. Reed,1 P. MacLennan,1 J. Locke.1

1University of Alabama at Birmingham, Birmingham
2University of Pennsylvania, Philadelphia

Meeting: 2017 American Transplant Congress

Abstract number: 162

Keywords: Cadaveric organs, Hepatitis C, Mortality

Session Information

Date: Sunday, April 30, 2017

Session Name: Concurrent Session: New Insights - HCV / HIV

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:06pm-5:18pm

Location: E271b

Related Abstracts
  • Low Expanded Criteria Donor Listing Rates by Organ Procurement Organization Is Associated With Increased Differential in Waiting Time for Candidates Willing to Accept Marginal Organs in the US
  • Superior Waitlist and Equivalent Transplant Outcomes Among Hepatitis C RNA-Positive Patients Who Are Willing to Accept Hepatitis C Seropositive Kidneys.

Background: HCV-infected ESRD patients derive a significant survival benefit from kidney transplantation (KT) over remaining on dialysis. Given the high mortality rates on dialysis and the unique ability to accept HCV+ and HCV- donors, understanding access to KT is essential.

Methods: 3,963 adult kidney-only candidates reported as willing to accept an HCV+ kidney (2008-2015) were identified from SRTR and defined as HCV+. Time-at-risk began at date of listing. Cumulative incidence of transplant and waitlist mortality were assessed using competing risks, and separate mixed effects Cox proportional hazards models were used to examine rates of waitlist mortality and transplantation. All models were adjusted for candidate demographic and clinical characteristics and included a random effect for listing OPO with nested listing center.

Results: HCV+ candidates were commonly older (50+: 82.6%), African-American (52.8%), and male (73.6%). Five years after listing 37.8% of candidates were transplanted with an HCV+ donor, 12.1% transplanted with an HCV- donor, and 23.6% died on the waitlist. Overall transplant rates exceeded waitlist mortality rates (22.69 vs. 11.45 per 100 PY), largely driven by transplantation with HCV+ donors (HCV+ donor: 17.72 vs. 4.97 per 100 PY). Conclusions: Among HCV+ waitlist candidates, rate of KT was highest with utilization of HCV+ donors, and importantly, these candidates were more likely to die waiting for KT than to achieve HCV-KT. In light of highly effective HCV therapies, it may be prudent to institute strategies to decrease waiting time and waitlist mortality for HCV+ candidates by increasing utilization of HCV+ donor kidneys.

CITATION INFORMATION: Shelton B, Sawinski D, Mehta S, Reed R, MacLennan P, Locke J. HCV+ Waitlist Candidates More Likely to Die Waiting for Kidney Transplant from HCV- Donor. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Shelton B, Sawinski D, Mehta S, Reed R, MacLennan P, Locke J. HCV+ Waitlist Candidates More Likely to Die Waiting for Kidney Transplant from HCV- Donor. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/hcv-waitlist-candidates-more-likely-to-die-waiting-for-kidney-transplant-from-hcv-donor/. Accessed January 21, 2021.

« Back to 2017 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Safety of Statin Therapy After Liver Transplantation.
  • Simultaneous Heart and Kidney Transplant vs Heart Transplant: Single Center Review of Candidate Selection and List Management.
  • Safety and Effectiveness of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Safety of Statin Therapy After Liver Transplantation.
  • Safety and Effectiveness of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.