Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti - HLA Antibodies After Kidney Transplantation

Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti – HLA Antibodies After Kidney Transplantation

H. Ko, S. Min, A. Han, S. Ahn, C. T. Chung, H. Kim, K. Choi, S. Min, H. Kang, J. Ha

Seoul National University Hospital, Seoul, Korea, Republic of

Meeting: 2021 American Transplant Congress

Abstract number: 1032

Keywords: Antibodies, Kidney transplantation, Rejection

Topic: Clinical Science » Kidney » Kidney Acute Antibody Mediated Rejection

Session Information

Session Name: Kidney Acute Antibody Mediated Rejection

Session Type: Poster Abstract

Session Date & Time: None. Available on demand.

Location: Virtual

*Purpose: The aim of this study was to investigate graft outcomes based on the presence of donor-specific anti-HLA antibodies (DSA) and the time of diagnosis in recipients with biopsy proven antibody-mediated rejection (ABMR) after kidney transplantation.

*Methods: Data were collected retrospectively for 136 recipients with histological ABMR after kidney transplantation between January 2010 and December 2018 in Seoul National University Hospital. We compared the graft outcome between the group of ABMR without anti-HLA DSA (DSA_negABMR) and the ABMR with anti-HLA DSA (DSA_posABMR). In addition, subgroup analysis was performed for the diagnosis time (within 2 weeks or after 2 weeks) of ABMR after kidney transplantation.

*Results: Of a total of 136 recipients with biopsy-proven ABMR, 67 (49.3%) were DSA_posABMR, and 69 (50.7%) were DSA_negABMR. The mean time to ABMR histologic diagnosis after kidney transplantation was 0.99 ± 1.93 years and 2.17 ± 2.35 years In the DSA_negABMR group and the DSA_posABMR group, respectively (p = 0.002). The mean fluorescence intensity (MFI) of DSA_posABMR was 8276 ± 8130. Although there was no statistically significant difference (p = 0.077), the DSA_negABMR group tended to have a superior graft survival rate compared to the DSA_posABMR group. The estimated glomerular filtration rate (eGFR) level was significantly higher in DSA_negABMR at the time of ABMR diagnosis (DSA_negABMR, 48.62 ± 30.60 mL/min/1.73m²; DSA_posABMR, 38.78 ± 22.99 mL/min/1.73m²; p = 0.036) and 1 year after diagnosis (DSA_negABMR, 53.85 ± 23.22 mL/min/1.73m²; DSA_posABMR, 42.83 ± 21.29 mL/min/1.73m²; p = 0.007). In the subgroup analysis of DSA_negABMR, ABMR diagnosed within 2 weeks after kidney transplantation had a graft survival rate superior to ABMR diagnosed after 2 weeks or more (p = 0.011). The subgroup analysis of DSA_posABMR also showed a similar pattern (p = 0.016).

*Conclusions: Our data demonstrate that DSA_negABMR diagnosed within 2 weeks after kidney transplantation had a superior graft survival rate.

To cite this abstract in AMA style:

Ko H, Min S, Han A, Ahn S, Chung CT, Kim H, Choi K, Min S, Kang H, Ha J. Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti – HLA Antibodies After Kidney Transplantation [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/graft-outcomes-of-antibody-mediated-rejection-without-donor-specific-anti-hla-antibodies-after-kidney-transplantation/. Accessed May 14, 2025.

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