ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Gender Disparity in Infections After Kidney Transplantation

S. Bae, L. Kucirka, C. Durand, B. Orandi, R. Avery, D. Segev.

Johns Hopkins, Baltimore, MD.

Meeting: 2015 American Transplant Congress

Abstract number: 355

Keywords: Infection, Kidney transplantation, Medicare

Session Information

Session Name: Concurrent Session: Disparities in Donation and Transplant Outcomes

Session Type: Concurrent Session

Date: Tuesday, May 5, 2015

Session Time: 2:15pm-3:45pm

 Presentation Time: 3:27pm-3:39pm

Location: Room 115-C

BACKGROUND: Female gender has been suggested as a risk factor for infection after kidney transplant (KT). Preliminary studies have reported that sex hormones such as estradiol may modulate immune responses. The goals of our study were to: 1) investigate gender disparities in risk of post-KT infections, and 2) examine whether the effect was attenuated in post-menopausal women.

METHODS: We studied 89355 first-time kidney transplant (KT) recipients with Medicare as their primary insurance from 1999-2010 as captured in USRDS. Infections that occurred in the year post-KT were ascertained via ICD-9 codes. Cox proportional hazards models were built to compare the hazard of infection by gender, adjusting for potential confounders. Analyses were stratified by age 50 to see whether gender differences were attenuated in post-menopausal women.

RESULTS: Females had higher hazards of UTI, sepsis, intestinal infections, C.difficile, candidiasis, herpes and adenoviruses, and respiratory viral infections (Table). There was no difference in the hazard of CMV and fungal infections, and females had a slightly lower hazard of pneumonia. Despite the higher hazard of infection, females had a similar hazard of death-censored graft loss and a lower risk of death. When stratified by age, gender disparities in sepsis and UTI were attenuated in those ≥ 50 (p<0.001). Although slightly attenuated, the gender disparities were still observed in those ≥ 50.​

CONCLUSION: Female kidney recipients have higher hazards of infection. This gender disparity is attenuated but not eliminated in those ≥ 50.

Table. Adjusted hazard ratio of infections comparing females to males

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Bae S, Kucirka L, Durand C, Orandi B, Avery R, Segev D. Gender Disparity in Infections After Kidney Transplantation [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/gender-disparity-in-infections-after-kidney-transplantation/. Accessed May 9, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences