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Enhancement of Endogenous omega-3 Protect against Ischemia-Reperfusion Renal Injury in Fat-1 Mice

D. Choi,1 Y. Ham,1 K. Na,1 K. Lee,1 J-.J. Kim,1,2 J. Jeong.1,3

1Nephrology, Chungnam National University, Daejeon, Korea
2Biomedical Science, Jungwon University, Chungbuk, Korea
3Medical Science, Chungnam National University, Daejeong, Korea.

Meeting: 2018 American Transplant Congress

Abstract number: B15

Keywords: Kidney transplantation, Renal failure

Session Information

Session Name: Poster Session B: Acute and Chronic Graft Injury

Session Type: Poster Session

Date: Sunday, June 3, 2018

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Introduction : Fat-1 transgenic mice produce [omega]3-Polyunsaturated fatty acids ([omega]3-PUFAs) from [omega]6-Polyunsaturated fatty acids ([omega]6-PUFAs) without a dietary [omega]3-PUFAs supplement, leading to a high accumulation of omega-3 in various tissues. [omega]3-PUFAs show protective effects against various renal injuries and it has recently been reported that [omega]3-PUFAs regulate autophagy. We assessed whether [omega]3-PUFAs attenuated IR-induced acute kidney injury (AKI) and evaluated its associated mechanisms.

Method : C57Bl/6 background fat-1 mice and wild-type mice (wt) were divided into four groups: wt sham (n = 10), fat-1 sham (n = 10), wt IRI (reperfusion 35 min after clamping both the renal artery and vein; n = 15), and fat-1 IRI (n = 15). Kidneys and blood were harvested 24 h after IRI and renal histological and molecular data were collected.

Results : The kidneys of fat-1 mice showed better renal cell survival, renal function, and pathological damage than those of wt mice after IRI. In addition, fat-1 mice showed less oxidative stress and autophagy impairment; greater amounts of microtubule-associated protein 1A/1B-light chain 3 (LC3)-II, Beclin-1, and Atg7; lower amounts of p62; and, higher levels of renal cathepsin D and ATP6E than wt kidneys. They also showed more adenosine monophosphate-activated protein kinase (AMPK) activation, which resulted in the inhibition of phosphorylation of the mammalian target of rapamycin (mTOR).

Conclusions : [omega]3-PUFAs in fat-1 mice contributed to AMPK mediated autophagy activation, leading to a renoprotective response.

CITATION INFORMATION: Choi D., Ham Y., Na K., Lee K., Kim J-.J., Jeong J. Enhancement of Endogenous omega-3 Protect against Ischemia-Reperfusion Renal Injury in Fat-1 Mice Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Choi D, Ham Y, Na K, Lee K, Kim J-J, Jeong J. Enhancement of Endogenous omega-3 Protect against Ischemia-Reperfusion Renal Injury in Fat-1 Mice [abstract]. https://atcmeetingabstracts.com/abstract/enhancement-of-endogenous-omega-3-protect-against-ischemia-reperfusion-renal-injury-in-fat-1-mice/. Accessed May 12, 2025.

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