ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Electrospun Poly-ε-Caprolactone Scaffolds Incorporating Decellularized Extracellular Matrix for Suturable Tissue Engineered Small Vascular Graft

A. Han1, S. Min1, E. Cho1, H. Woo1, A. Cho1, J. Ha1, Y. Ju2, S. Min1

1Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

Meeting: 2022 American Transplant Congress

Abstract number: 180

Keywords: N/A

Topic: Basic Science » Basic Science » 06 - Tissue Engineering and Regenerative Medicine

Session Information

Session Name: Cellular/Islet Therapies and Tissue Engineering

Session Type: Rapid Fire Oral Abstract

Date: Sunday, June 5, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 6:10pm-6:20pm

Location: Hynes Room 310

*Purpose: While small-sized grafts (1-5mm in diameter) are essential vascular conduits needed to replace diseased end arteries supplying vital organs or tissues, the use of synthetic grafts is limited due to high rates of thrombosis. Enhancing cellular recruitment to scaffolds of tissue-engineered vascular grafts (TEVG) is an essential first step towards less thrombogenic vascular graft. To enhance cellular recruitment and achieve better cellular mimicry, we have developed a TEVG using electrospun poly-ε-caprolactone (PCL)/ decellularized extracellular matrix (dECM) composite scaffolds.

*Methods: An electrospun acellular hybrid scaffold was fabricated using PCL and dECM from the rat aorta. The surface morphology of the PCL/dECM graft was characterized using scanning electron microscopy (SEM). Mechanical properties including longitudinal elastic modulus and tensile strength were examined. In vitro biocompatibility was assessed using an MTT assay. The In vivo performance PCL/dECM graft was evaluated in the rat aorta interposition model and was compared to the performance of PCL-only graft and syngeneic aortic graft.

*Results: PCL/dECM electrospun TEVG with a diameter of 1mm was successfully fabricated. Compared to electrospun grafts made of PCL only, PCL/dECM graft showed a larger fiber diameter and greater porosity. While the two grafts’ tensile strength was comparable, Young’s modulus of PCL/dECM grafts was lower. 10 PCL/ECM grafts and 10 PCL grafts were used to replace the aorta of 20 rats. 17 survived till graft explantation. The degree of lumen occlusion or neointimal hyperplasia after 4 and 12 weeks after graft implantation was not statistically different between syngeneic, PCL-only, and PCL/dECM graft. While PCL/dECM graft showed earlier infiltration of host cells into grafts, it was limited by earlier graft degradation compared to PCL.

*Conclusions: PCL/ ECM hybrid polymer-based electrospun graft showed comparable tensile strength and better early cellular recruitment in vivo compared to PCL-only graft. However, the in vivo performance of PCL/ECM graft was limited due to early degradation.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Han A, Min S, Cho E, Woo H, Cho A, Ha J, Ju Y, Min S. Electrospun Poly-ε-Caprolactone Scaffolds Incorporating Decellularized Extracellular Matrix for Suturable Tissue Engineered Small Vascular Graft [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/electrospun-poly-%ce%b5-caprolactone-scaffolds-incorporating-decellularized-extracellular-matrix-for-suturable-tissue-engineered-small-vascular-graft/. Accessed May 30, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences