Living kidney donation has significantly improved recipient and graft survival world wide. It is importanat to have a better understanding of the outcomes and risks of kidney donation.

We analysed the effect of baseline proteinuria and short and long term outcomes in live kidney donors. From January 1, 2001 until December 31, 2013 inclusive, all live kidney donors in the U.K were included in the study. No formal sample size estimate was produced for the study; all eligible patients records were used. December 31, 2014 was considered the study end, meaning that all patients had at least one year of follow-up. Datasets, based on regular returns from individual transplant centres across the UK, were obtained from NHSBT.

There were 9750 donor records available. Out of which 9500 donors were tested for proteinuria at baseline. 8858 had no evidence. 437 had trace, 182 had 1+, 18 had 2+ and 5 had 3+ proteinuria. There were no significant relationships between baseline proteinuria and 1, 5 and 10 year mortality and morbidity outcomes. Multiple logistic regression models adjusted for age and sex was used to analyse baseline comorbidities and proteinuria at 1 year . The baseline comorbidities analysed were gender, ethnicity, GFR risk groups (1. meeting the recommended levels. 2. up to 5 mls/min/m2 less than the recommended levels and 3. more than 5 mls/min/m2 less than the recommended levels), different BMI bands, BMI <18.5 , 18.5 -<25, 25-<30, 30-<35, 35-<40, 40+ , cardio vascular disease, kidney stones or renal mention, microscopic haematuria, hypertension. diabetes, depression, asthma, hypercholesterolemia and any morbidity.

Proteinuria was more prevalent and statistically significant in male donors (P=0.012). Ethnicity was of borderline significance, with white ethnicity having less frequent proteinuria (P=0.052). BMI bands suggested a trend towards an increase in frequency of proteinuria as BMI increased (P=0.037); Higher proportion of kidney mention patients had proteinuria at 1 year and this was statistically significant (P=0,031). Patients with any baseline morbidity were more likely to have proteinuria (P=0.009). Baseline proteinuria did not have significant association with morbidity or mortality at 1 year. However, certain baseline comorbidities were significantly associated with proteinuria at 1 year.

CITATION INFORMATION: Krishnan N, Bradbury L, Raymond N. Effect of Baseline Proteinuria on Long- and Short-Term Outcomes in Live Kidney Donors – 10 Year U.K Cohort Study. Am J Transplant. 2016;16 (suppl 3).

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