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Dynapenia Among Kidney Transplant Candidates and Recipients in the United States

A. S. Nalatwad1, X. Chen1, N. M. Chu1, S. P. Norman2, D. L. Segev1, M. McAdams-Demarco1

1Epidemiology Research Group in Organ Transplantation, Johns Hopkins University School of Medicine, Baltimore, MD, 2Univ of Michigan Medical Ctr, Ann Arbor, MI

Meeting: 2022 American Transplant Congress

Abstract number: 744

Keywords: Kidney/liver transplantation, Renal failure

Topic: Clinical Science » Kidney » 32 - Kidney Deceased Donor Selection

Session Information

Session Name: Kidney Deceased Donor Selection

Session Type: Poster Abstract

Date: Saturday, June 4, 2022

Session Time: 5:30pm-7:00pm

 Presentation Time: 5:30pm-7:00pm

Location: Hynes Halls C & D

*Purpose: Among Kidney Transplant (KT) patients, sarcopenia, loss of muscle mass, is prevalent and has been associated with post-KT mortality. The burden of dynapenia, an age-related loss of muscle strength and a downstream consequence of sarcopenia, is unclear. Therefore, we studied the prevalence of dynapenia using the Short Physical Performance Battery (SPPB) among kidney transplant candidates and recipients.

*Methods: In a prospective cohort study (2009-2021) comprising of 3545 adult KT candidates enrolled at evaluation and 940 adult KT recipients enrolled at admission, SPPB (gait speed, chair stands and balance) was measured at enrollment. A SPPB score of <10 was defined as dynapenia. Prevalence of dynapenia was compared by age (18-64 and ≥65 years). Logistic regressions were used to identify correlates of dynapenia.

*Results: 26.8% of candidates and 19.6% of recipients were older. At evaluation for KT, dynapenia prevalence was 50.5% in younger candidates and 68.4% in older candidates. At admission for KT, dynapenia prevalence was 47.8% in younger candidates and 72.3% in older candidates (Figure 1). Dynapenia was associated with older age, Black race, and obese in both cohorts, while also associated with sex, type of dialysis, and overweight in candidates.

*Conclusions: KT patients experience a high burden of dynapenia even at younger ages. Providers should be more intentional in monitoring for dynapenia in minority and older groups.

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To cite this abstract in AMA style:

Nalatwad AS, Chen X, Chu NM, Norman SP, Segev DL, McAdams-Demarco M. Dynapenia Among Kidney Transplant Candidates and Recipients in the United States [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/dynapenia-among-kidney-transplant-candidates-and-recipients-in-the-united-states/. Accessed May 9, 2025.

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