Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: The outcomes of transplantation have been improved, but more than 50% of kidney transplantation recipients were still reported to have renal function of chronic kidney disease (CKD) stage 3 at 1 year after kidney transplantation. In addition, transplant recipients with CKD stage 3b had poorer graft survival than the recipients with CKD stage 3a. Therefore, knowledge about risk factors and different clinical courses are important to improve the outcomes.
Methods: We reviewed all 1235 patients who received a kidney transplantation in our institution in 2008 and 2012. Among these recipients, 77 and 289 cases were included in the estimated glomerular filtration rate (eGFR) 30-44 group and eGFR 45-59 group, respectively. These patients were followed until June 2015 and contributing factors for eGFR of 30-44 mL/min and clinical courses of each group were compared.
Results: Longer duration of dialysis [odds ratio (OR)=1.007, 95% confidence interval (CI), 1.000-1.014, P=0.047], older donors (OR=1.064, 95% CI, 1.031-1.098, p<0.001), delayed graft function (OR=3.601, 95% CI, 1.031-1.098, p<0.001), BK virus infection (OR=2.567, 95% CI, 1.242-5.305, p=0.011) and pneumonia (OR=4.451, 95% CI, 1.388-14.279, p=0.012) were contributing factors of eGFR 30-44 ml/min. Especially, ureteral stricture occurred more frequently in eGFR 30-44 group of deceased donor kidney transplantation. However, acute rejection was not a significant risk factor of lower eGFR. After 1 year of transplantation, rejection occurred more frequently in eGFR 30-44 group. Graft survival was better in the eGFR 45-59 group. However, this difference lessened in deceased donor kidney transplantation.
Conclusions: Infections and urologic complications are also important contributing factors of lower graft function in CKD stage 3. In addition, dividing CKD stage 3 to subgroups might be more useful in living donor kidney transplantation. Clinicians should also pay attention to nonimmunologic risk factors for poor graft function.
CITATION INFORMATION: Baek C, Kim H, Yang W, Han D, Park S.-K. Differential Characteristics of Kidney Transplant Recipients According to 1-Year Chronic Kidney Disease Stage 3a and Stage 3b Graft Function. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Baek C, Kim H, Yang W, Han D, Park S-K. Differential Characteristics of Kidney Transplant Recipients According to 1-Year Chronic Kidney Disease Stage 3a and Stage 3b Graft Function. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/differential-characteristics-of-kidney-transplant-recipients-according-to-1-year-chronic-kidney-disease-stage-3a-and-stage-3b-graft-function/. Accessed February 26, 2020.
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