Background: Pancreas transplant remains controversial for type 2 diabetic (T2DM) patients.

Aim: To compare glycemic control following pancreas transplantation between T1 and T2 DM patients.

Methods: 52 recipients who underwent deceased donor pancreas transplant between 2013 and 2016 at our institution were retrospectively reviewed. The analysis included simultaneous kidney pancreas, pancreas after kidney and pancreas transplant alone patients. Transplant candidacy of T2DM patients was determined according to the following criteria: age <55, BMI <30 kg/m2, total insulin requirements <1U/kg/d, fasting c-peptide <10 ng/mL. Fasting glucose (FG) levels and BMI were compared at pre-op, immediately post-op and at 3, 6 and 9 months. Two sample t-tests and Wilcoxon-Mann-Whitney tests were conducted for comparisons.

Results: Of the total of 52 patients, 33 were DM1 (63%) and 19 were DM2 (37%). Post-operative glucose control was excellent in both groups and was similar at 3, 6 and 9 months. BMI at pre-op, 3, 6 and 9 months were slightly higher in T2DM group but this was statistically not significant. Conclusions: T2DM patients achieved equal glycemic control compared to T1DM in the 1^st year following transplant. In carefully selected non-obese DM2 patients, pancreas transplant provides excellent control of the disease. Active pancreas transplant centers should continue this curative therapy in appropriate patients with both T1 and T2DM.

CITATION INFORMATION: Andacoglu O., Murthy A., Ahn J., Verbesey J., Ghasemian S., Cooper M., Abrams P. Comparison of Glycemic Control in Type 1 and Type 2 Diabetic Patients after Pancreas Transplantation Am J Transplant. 2017;17 (suppl 3).

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